Changes in the expression of the Alzheimer's disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction
Mutations in the presenilin genes cause the majority of early-onset familial Alzheimer’s disease. Recently, presenilin mutations have been identified in patients with dilated cardiomyopathy (DCM), a common cause of heart failure and the most prevalent diagnosis in cardiac transplantation patients...
Main Authors: | Li, A., Zhou, C., Moore, J., Zhang, P., Tsai, Tsung-Han, Lee, Hsiang-Chieh, Romano, D. M., McKee, M. L., Schoenfeld, D. A., Serra, M. J., Raygor, K., Cantiello, H. F., Fujimoto, James G., Tanzi, R. E. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
Format: | Article |
Language: | en_US |
Published: |
Bentham Science Publishers
2012
|
Online Access: | http://hdl.handle.net/1721.1/72433 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
Similar Items
-
Presenilin-1 polymorphism and Alzheimer's disease [6]
by: Kehoe, P, et al.
Published: (1996) -
Interaction of Presenilin-1 C-terminal fragment with FKBP38
by: Tai, Jeff Seng Thong
Published: (2008) -
Neddylation dysfunction in Alzheimer's disease
by: Chen, Yuzhi, et al.
Published: (2014) -
Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease
by: Shin, Yoojin, et al.
Published: (2021) -
Abnormal cardiac energetics are associated with diastolic dysfunction in uncomplicated obesity
by: Robinson, M, et al.
Published: (2006)