Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes
Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve significantly faster than spliced genes. By contrast, monomorphic spliced genes tha...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Oxford University Press on behalf of the Society for Molecular Biology and Evolution
2012
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| Online Access: | http://hdl.handle.net/1721.1/72441 |
| _version_ | 1826209600941064192 |
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| author | Shabalina, Svetlana A. Ogurtsov, Aleksey Y. Spiridonov, Alexey Nikolaevich Novichkov, Pavel S. Spiridonov, Nikolay A. Koonin, Eugene V. |
| author2 | Massachusetts Institute of Technology. Department of Mathematics |
| author_facet | Massachusetts Institute of Technology. Department of Mathematics Shabalina, Svetlana A. Ogurtsov, Aleksey Y. Spiridonov, Alexey Nikolaevich Novichkov, Pavel S. Spiridonov, Nikolay A. Koonin, Eugene V. |
| author_sort | Shabalina, Svetlana A. |
| collection | MIT |
| description | Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve significantly faster than spliced genes. By contrast, monomorphic spliced genes that are not subject to detectable alternative splicing and polymorphic alternatively spliced genes show similar statistically indistinguishable patterns of expression and evolution. Alternative splicing is most common in ancient genes, whereas intronless genes appear to have relatively recent origins. These results imply tight coupling between different stages of gene expression, in particular, transcription, splicing, and nucleocytosolic transport of transcripts, and suggest that formation of intronless genes is an important route of evolution of novel tissue-specific functions in animals. |
| first_indexed | 2024-09-23T14:25:25Z |
| format | Article |
| id | mit-1721.1/72441 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:25:25Z |
| publishDate | 2012 |
| publisher | Oxford University Press on behalf of the Society for Molecular Biology and Evolution |
| record_format | dspace |
| spelling | mit-1721.1/724412022-09-29T09:21:56Z Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes Shabalina, Svetlana A. Ogurtsov, Aleksey Y. Spiridonov, Alexey Nikolaevich Novichkov, Pavel S. Spiridonov, Nikolay A. Koonin, Eugene V. Massachusetts Institute of Technology. Department of Mathematics Spiridonov, Alexey Nikolaevich Spiridonov, Alexey Nikolaevich Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve significantly faster than spliced genes. By contrast, monomorphic spliced genes that are not subject to detectable alternative splicing and polymorphic alternatively spliced genes show similar statistically indistinguishable patterns of expression and evolution. Alternative splicing is most common in ancient genes, whereas intronless genes appear to have relatively recent origins. These results imply tight coupling between different stages of gene expression, in particular, transcription, splicing, and nucleocytosolic transport of transcripts, and suggest that formation of intronless genes is an important route of evolution of novel tissue-specific functions in animals. United States. Dept. of Health and Human Services National Institutes of Health (U.S.) National Library of Medicine (U.S.) (intramural funds) 2012-08-29T20:11:07Z 2012-08-29T20:11:07Z 2010-04 Article http://purl.org/eprint/type/JournalArticle 0737-4038 1537-1719 http://hdl.handle.net/1721.1/72441 Shabalina, S. A. et al. “Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes.” Molecular Biology and Evolution 27.8 (2010): 1745–1749. Web. en_US http://dx.doi.org/10.1093/molbev/msq086 Molecular Biology and Evolution Creative Commons Attribution Non-Commercial http://creativecommons.org/licenses/by-nc/2.5 application/pdf Oxford University Press on behalf of the Society for Molecular Biology and Evolution Oxford |
| spellingShingle | Shabalina, Svetlana A. Ogurtsov, Aleksey Y. Spiridonov, Alexey Nikolaevich Novichkov, Pavel S. Spiridonov, Nikolay A. Koonin, Eugene V. Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title | Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title_full | Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title_fullStr | Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title_full_unstemmed | Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title_short | Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes |
| title_sort | distinct patterns of expression and evolution of intronless and intron containing mammalian genes |
| url | http://hdl.handle.net/1721.1/72441 |
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