Control of the mitotic exit network during meiosis
The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to the timely exit from meiosis II. Consistent with a role for the MEN during mei...
| প্রধান লেখক: | , |
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| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | en_US |
| প্রকাশিত: |
American Society for Cell Biology
2012
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/72485 https://orcid.org/0000-0001-9837-0314 |
| _version_ | 1826199216042541056 |
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| author | Attner, Michelle Andrea Amon, Angelika B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Attner, Michelle Andrea Amon, Angelika B |
| author_sort | Attner, Michelle Andrea |
| collection | MIT |
| description | The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to the timely exit from meiosis II. Consistent with a role for the MEN during meiosis II, we find that the signaling pathway is active only during meiosis II. Our analysis further shows that MEN signaling is modulated during meiosis in several key ways. Whereas binding of MEN components to spindle pole bodies (SPBs) is necessary for MEN signaling during mitosis, during meiosis MEN signaling occurs off SPBs and does not require the SPB recruitment factor Nud1. Furthermore, unlike during mitosis, MEN signaling is controlled through the regulated interaction between the MEN kinase Dbf20 and its activating subunit Mob1. Our data lead to the conclusion that a pathway essential for vegetative growth is largely dispensable for the specialized meiotic divisions and provide insights into how cell cycle regulatory pathways are modulated to accommodate different modes of cell division. |
| first_indexed | 2024-09-23T11:16:33Z |
| format | Article |
| id | mit-1721.1/72485 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:16:33Z |
| publishDate | 2012 |
| publisher | American Society for Cell Biology |
| record_format | dspace |
| spelling | mit-1721.1/724852022-09-27T18:21:23Z Control of the mitotic exit network during meiosis Attner, Michelle Andrea Amon, Angelika B Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Amon, Angelika B. Attner, Michelle Andrea Amon, Angelika B. The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to the timely exit from meiosis II. Consistent with a role for the MEN during meiosis II, we find that the signaling pathway is active only during meiosis II. Our analysis further shows that MEN signaling is modulated during meiosis in several key ways. Whereas binding of MEN components to spindle pole bodies (SPBs) is necessary for MEN signaling during mitosis, during meiosis MEN signaling occurs off SPBs and does not require the SPB recruitment factor Nud1. Furthermore, unlike during mitosis, MEN signaling is controlled through the regulated interaction between the MEN kinase Dbf20 and its activating subunit Mob1. Our data lead to the conclusion that a pathway essential for vegetative growth is largely dispensable for the specialized meiotic divisions and provide insights into how cell cycle regulatory pathways are modulated to accommodate different modes of cell division. National Institutes of Health (U.S.) (Grant number GM62207) Howard Hughes Medical Institute. Investigator 2012-08-30T18:51:36Z 2012-08-30T18:51:36Z 2012-06 2012-06 Article http://purl.org/eprint/type/JournalArticle 1059-1524 1939-4586 http://hdl.handle.net/1721.1/72485 Attner, M. A., and A. Amon. “Control of the Mitotic Exit Network During Meiosis.” Molecular Biology of the Cell 23.16 (2012): 3122–3132. Copyright © 2012 by The American Society for Cell Biology https://orcid.org/0000-0001-9837-0314 en_US http://dx.doi.org/10.1091/mbc.E12-03-0235 Molecular Biology of the Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Society for Cell Biology American Society for Cell Biology |
| spellingShingle | Attner, Michelle Andrea Amon, Angelika B Control of the mitotic exit network during meiosis |
| title | Control of the mitotic exit network during meiosis |
| title_full | Control of the mitotic exit network during meiosis |
| title_fullStr | Control of the mitotic exit network during meiosis |
| title_full_unstemmed | Control of the mitotic exit network during meiosis |
| title_short | Control of the mitotic exit network during meiosis |
| title_sort | control of the mitotic exit network during meiosis |
| url | http://hdl.handle.net/1721.1/72485 https://orcid.org/0000-0001-9837-0314 |
| work_keys_str_mv | AT attnermichelleandrea controlofthemitoticexitnetworkduringmeiosis AT amonangelikab controlofthemitoticexitnetworkduringmeiosis |