Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving immunological self-tolerance in differentiating T cells. To elucidate its mechanistic pathways, we examined its transcriptional impact in MECs in vivo...

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Bibliographic Details
Main Authors: Giraud, Matthieu, Yoshida, Hideyuki, Abramson, Jakub, Rahl, Peter B., Young, Richard A., Mathis, Diane, Benoist, Christophe
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/72512
https://orcid.org/0000-0001-8855-8647

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