Localization of magnetic pills
Numerous therapeutics demonstrate optimal absorption or activity at specific sites in the gastrointestinal (GI) tract. Yet, safe, effective pill retention within a desired region of the GI remains an elusive goal. We report a safe, effective method for localizing magnetic pills. To ensure safety and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences
2012
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| Online Access: | http://hdl.handle.net/1721.1/72528 |
| _version_ | 1811086753733279744 |
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| author | Laulicht, Bryan E. Gidmark, Nicholas J. Tripathi, Anubhav Mathiowitz, Edith |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Laulicht, Bryan E. Gidmark, Nicholas J. Tripathi, Anubhav Mathiowitz, Edith |
| author_sort | Laulicht, Bryan E. |
| collection | MIT |
| description | Numerous therapeutics demonstrate optimal absorption or activity at specific sites in the gastrointestinal (GI) tract. Yet, safe, effective pill retention within a desired region of the GI remains an elusive goal. We report a safe, effective method for localizing magnetic pills. To ensure safety and efficacy, we monitor and regulate attractive forces between a magnetic pill and an external magnet, while visualizing internal dose motion in real time using biplanar videofluoroscopy. Real-time monitoring yields direct visual confirmation of localization completely noninvasively, providing a platform for investigating the therapeutic benefits imparted by localized oral delivery of new and existing drugs. Additionally, we report the in vitro measurements and calculations that enabled prediction of successful magnetic localization in the rat small intestines for 12 h. The designed system for predicting and achieving successful magnetic localization can readily be applied to any area of the GI tract within any species, including humans. The described system represents a significant step forward in the ability to localize magnetic pills safely and effectively anywhere within the GI tract. What our magnetic pill localization strategy adds to the state of the art, if used as an oral drug delivery system, is the ability to monitor the force exerted by the pill on the tissue and to locate the magnetic pill within the test subject all in real time. This advance ensures both safety and efficacy of magnetic localization during the potential oral administration of any magnetic pill-based delivery system. |
| first_indexed | 2024-09-23T13:34:12Z |
| format | Article |
| id | mit-1721.1/72528 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:34:12Z |
| publishDate | 2012 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/725282022-09-28T14:41:28Z Localization of magnetic pills Laulicht, Bryan E. Gidmark, Nicholas J. Tripathi, Anubhav Mathiowitz, Edith Massachusetts Institute of Technology. Department of Mechanical Engineering Laulicht, Bryan E. Laulicht, Bryan E. Numerous therapeutics demonstrate optimal absorption or activity at specific sites in the gastrointestinal (GI) tract. Yet, safe, effective pill retention within a desired region of the GI remains an elusive goal. We report a safe, effective method for localizing magnetic pills. To ensure safety and efficacy, we monitor and regulate attractive forces between a magnetic pill and an external magnet, while visualizing internal dose motion in real time using biplanar videofluoroscopy. Real-time monitoring yields direct visual confirmation of localization completely noninvasively, providing a platform for investigating the therapeutic benefits imparted by localized oral delivery of new and existing drugs. Additionally, we report the in vitro measurements and calculations that enabled prediction of successful magnetic localization in the rat small intestines for 12 h. The designed system for predicting and achieving successful magnetic localization can readily be applied to any area of the GI tract within any species, including humans. The described system represents a significant step forward in the ability to localize magnetic pills safely and effectively anywhere within the GI tract. What our magnetic pill localization strategy adds to the state of the art, if used as an oral drug delivery system, is the ability to monitor the force exerted by the pill on the tissue and to locate the magnetic pill within the test subject all in real time. This advance ensures both safety and efficacy of magnetic localization during the potential oral administration of any magnetic pill-based delivery system. Brown University 2012-09-05T18:02:51Z 2012-09-05T18:02:51Z 2011-02 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/72528 Laulicht, B. et al. “Localization of Magnetic Pills.” Proceedings of the National Academy of Sciences 108.6 (2011): 2252–2257. Copyright ©2011 by the National Academy of Sciences en_US http://dx.doi.org/10.1073/pnas.1016367108 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Laulicht, Bryan E. Gidmark, Nicholas J. Tripathi, Anubhav Mathiowitz, Edith Localization of magnetic pills |
| title | Localization of magnetic pills |
| title_full | Localization of magnetic pills |
| title_fullStr | Localization of magnetic pills |
| title_full_unstemmed | Localization of magnetic pills |
| title_short | Localization of magnetic pills |
| title_sort | localization of magnetic pills |
| url | http://hdl.handle.net/1721.1/72528 |
| work_keys_str_mv | AT laulichtbryane localizationofmagneticpills AT gidmarknicholasj localizationofmagneticpills AT tripathianubhav localizationofmagneticpills AT mathiowitzedith localizationofmagneticpills |