Function-based Intersubject Alignment of Human Cortical Anatomy
Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Oxford University Press
2012
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| Online Access: | http://hdl.handle.net/1721.1/73053 https://orcid.org/0000-0002-5002-1227 |
| _version_ | 1811072044593315840 |
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| author | Sabuncu, Mert R. Singer, Benjamin D. Conroy, Bryan, Bryan, Ronald E. Ramadge, Peter J. Haxby, James V. |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Sabuncu, Mert R. Singer, Benjamin D. Conroy, Bryan, Bryan, Ronald E. Ramadge, Peter J. Haxby, James V. |
| author_sort | Sabuncu, Mert R. |
| collection | MIT |
| description | Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis. |
| first_indexed | 2024-09-23T09:00:02Z |
| format | Article |
| id | mit-1721.1/73053 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:00:02Z |
| publishDate | 2012 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | mit-1721.1/730532021-09-09T17:02:24Z Function-based Intersubject Alignment of Human Cortical Anatomy Sabuncu, Mert R. Singer, Benjamin D. Conroy, Bryan, Bryan, Ronald E. Ramadge, Peter J. Haxby, James V. Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Sabuncu, Mert R. Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis. National Institute of Mental Health (U.S.) (Grant 5R01MH075706) 2012-09-19T19:32:03Z 2012-09-19T19:32:03Z 2009-05 Article http://purl.org/eprint/type/JournalArticle 1047-3211 1460-2199 http://hdl.handle.net/1721.1/73053 Sabuncu, M. R. et al. “Function-based Intersubject Alignment of Human Cortical Anatomy.” Cerebral Cortex 20.1 (2009): 130–140. https://orcid.org/0000-0002-5002-1227 en_US http://dx.doi.org/10.1093/cercor/bhp085 Cerebral Cortex Creative Commons Attribution Non-Commercial http://creativecommons.org/licenses/by-nc/2.5 application/pdf Oxford University Press Oxford |
| spellingShingle | Sabuncu, Mert R. Singer, Benjamin D. Conroy, Bryan, Bryan, Ronald E. Ramadge, Peter J. Haxby, James V. Function-based Intersubject Alignment of Human Cortical Anatomy |
| title | Function-based Intersubject Alignment of Human Cortical Anatomy |
| title_full | Function-based Intersubject Alignment of Human Cortical Anatomy |
| title_fullStr | Function-based Intersubject Alignment of Human Cortical Anatomy |
| title_full_unstemmed | Function-based Intersubject Alignment of Human Cortical Anatomy |
| title_short | Function-based Intersubject Alignment of Human Cortical Anatomy |
| title_sort | function based intersubject alignment of human cortical anatomy |
| url | http://hdl.handle.net/1721.1/73053 https://orcid.org/0000-0002-5002-1227 |
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