Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit
Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm at 100kHz a...
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| Format: | Article |
| Language: | en_US |
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Optical Society of America
2012
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| Online Access: | http://hdl.handle.net/1721.1/73055 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811087669068824576 |
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| author | Baumann, Bernhard Choi, Woo Jhon Potsaid, Benjamin M. Huang, David Duker, Jay S. Fujimoto, James G. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Baumann, Bernhard Choi, Woo Jhon Potsaid, Benjamin M. Huang, David Duker, Jay S. Fujimoto, James G. |
| author_sort | Baumann, Bernhard |
| collection | MIT |
| description | Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm at 100kHz axial scan rates using single mode fiber optics and a multiplexing approach. Unlike previously reported PS-OCT multiplexing schemes, the method uses a passive polarization delay unit and does not require active polarization modulating devices. This advance decreases system cost and avoids complex synchronization requirements. The polarization delay unit was implemented in the sample beam path in order to simultaneously illuminate the sample with two different polarization states. The orthogonal polarization components for the depth-multiplexed signals from the two input states were detected using dual balanced detection. PS-OCT images were computed using Jones calculus. 3D PS-OCT imaging was performed in the human and rat retina. In addition to standard OCT images, PS-OCT images were generated using contrast form birefringence and depolarization. Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images. |
| first_indexed | 2024-09-23T13:50:07Z |
| format | Article |
| id | mit-1721.1/73055 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:50:07Z |
| publishDate | 2012 |
| publisher | Optical Society of America |
| record_format | dspace |
| spelling | mit-1721.1/730552022-09-28T16:29:22Z Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit Baumann, Bernhard Choi, Woo Jhon Potsaid, Benjamin M. Huang, David Duker, Jay S. Fujimoto, James G. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Fujimoto, James G. Baumann, Bernhard Choi, Woo Jhon Potsaid, Benjamin M. Fujimoto, James G. Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm at 100kHz axial scan rates using single mode fiber optics and a multiplexing approach. Unlike previously reported PS-OCT multiplexing schemes, the method uses a passive polarization delay unit and does not require active polarization modulating devices. This advance decreases system cost and avoids complex synchronization requirements. The polarization delay unit was implemented in the sample beam path in order to simultaneously illuminate the sample with two different polarization states. The orthogonal polarization components for the depth-multiplexed signals from the two input states were detected using dual balanced detection. PS-OCT images were computed using Jones calculus. 3D PS-OCT imaging was performed in the human and rat retina. In addition to standard OCT images, PS-OCT images were generated using contrast form birefringence and depolarization. Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images. National Institutes of Health (U.S.) (NIH R01-EY011289-25) National Institutes of Health (U.S.) (R01-EY013178-12) National Institutes of Health (U.S.) (R01-EY013516-09) National Institutes of Health (U.S.) (R01-EY019029-04) National Institutes of Health (U.S.) (R01-EY018184-05) National Institutes of Health (U.S.) (R01-CA075289-14) National Institutes of Health (U.S.) (R01-HL095717-03) National Institutes of Health (U.S.) (R01-NS057476-05) United States. Air Force Office of Scientific Research (AFOSR FA9550-10-1-0063) United States. Dept. of Defense. Medical Free Electron Laser Program (FA9550-07-1-0101) 2012-09-19T19:42:53Z 2012-09-19T19:42:53Z 2012-04 2012-04 Article http://purl.org/eprint/type/JournalArticle 1094-4087 http://hdl.handle.net/1721.1/73055 Baumann, Bernhard et al. “Swept Source / Fourier Domain Polarization Sensitive Optical Coherence Tomography with a Passive Polarization Delay Unit.” Optics Express 20.9 (2012): 10229. https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1364/OE.20.010229 Optics Express Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Optical Society of America PubMed Central |
| spellingShingle | Baumann, Bernhard Choi, Woo Jhon Potsaid, Benjamin M. Huang, David Duker, Jay S. Fujimoto, James G. Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title | Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title_full | Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title_fullStr | Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title_full_unstemmed | Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title_short | Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| title_sort | swept source fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit |
| url | http://hdl.handle.net/1721.1/73055 https://orcid.org/0000-0002-0828-4357 |
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