Connections between Alternative Transcription and Alternative Splicing in Mammals
The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT). Comparative analysis of the number of alternative nucleotides, isoforms, and introns per locus in g...
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| Format: | Article |
| Language: | en_US |
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Oxford University Press (OUP)
2012
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| Online Access: | http://hdl.handle.net/1721.1/73061 |
| _version_ | 1826208218594934784 |
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| author | Spiridonov, Alexey Nikolaevich Shabalina, Svetlana A. Spiridonov, Nikolay A. Koonin, Eugene V. |
| author2 | Massachusetts Institute of Technology. Department of Mathematics |
| author_facet | Massachusetts Institute of Technology. Department of Mathematics Spiridonov, Alexey Nikolaevich Shabalina, Svetlana A. Spiridonov, Nikolay A. Koonin, Eugene V. |
| author_sort | Spiridonov, Alexey Nikolaevich |
| collection | MIT |
| description | The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT). Comparative analysis of the number of alternative nucleotides, isoforms, and introns per locus in genes with different types of alternative events suggests that ATI and ATT contribute to the diversity of human and mouse transcriptome even more than AS. There is a strong negative correlation between AS and ATI in 5′ untranslated regions (UTRs) and AS in coding sequences (CDSs) but an even stronger positive correlation between AS in CDSs and ATT in 3′ UTRs. These observations could reflect preferential regulation of distinct, large groups of genes by different mechanisms: 1) regulation at the level of transcription initiation and initiation of translation resulting from ATI and AS in 5′ UTRs and 2) posttranslational regulation by different protein isoforms. The tight linkage between AS in CDSs and ATT in 3′ UTRs suggests that variability of 3′ UTRs mediates differential translational regulation of alternative protein forms. Together, the results imply coordinate evolution of AS and alternative transcription, processes that occur concomitantly within gene expression factories. |
| first_indexed | 2024-09-23T14:02:04Z |
| format | Article |
| id | mit-1721.1/73061 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:02:04Z |
| publishDate | 2012 |
| publisher | Oxford University Press (OUP) |
| record_format | dspace |
| spelling | mit-1721.1/730612022-09-22T10:59:44Z Connections between Alternative Transcription and Alternative Splicing in Mammals Spiridonov, Alexey Nikolaevich Shabalina, Svetlana A. Spiridonov, Nikolay A. Koonin, Eugene V. Massachusetts Institute of Technology. Department of Mathematics Spiridonov, Alexey Nikolaevich The majority of mammalian genes produce multiple transcripts resulting from alternative splicing (AS) and/or alternative transcription initiation (ATI) and alternative transcription termination (ATT). Comparative analysis of the number of alternative nucleotides, isoforms, and introns per locus in genes with different types of alternative events suggests that ATI and ATT contribute to the diversity of human and mouse transcriptome even more than AS. There is a strong negative correlation between AS and ATI in 5′ untranslated regions (UTRs) and AS in coding sequences (CDSs) but an even stronger positive correlation between AS in CDSs and ATT in 3′ UTRs. These observations could reflect preferential regulation of distinct, large groups of genes by different mechanisms: 1) regulation at the level of transcription initiation and initiation of translation resulting from ATI and AS in 5′ UTRs and 2) posttranslational regulation by different protein isoforms. The tight linkage between AS in CDSs and ATT in 3′ UTRs suggests that variability of 3′ UTRs mediates differential translational regulation of alternative protein forms. Together, the results imply coordinate evolution of AS and alternative transcription, processes that occur concomitantly within gene expression factories. 2012-09-20T14:02:55Z 2012-09-20T14:02:55Z 2010-10 2010-09 Article http://purl.org/eprint/type/JournalArticle 1759-6653 http://hdl.handle.net/1721.1/73061 Shabalina, S. A. et al. “Connections Between Alternative Transcription and Alternative Splicing in Mammals.” Genome Biology and Evolution 2.0 (2010): 791–799. en_US http://dx.doi.org/10.1093/gbe/evq058 Genome Biology and Evolution Creative Commons Attribution Non-Commercial http://creativecommons.org/licenses/by-nc/2.5 application/pdf Oxford University Press (OUP) Oxford |
| spellingShingle | Spiridonov, Alexey Nikolaevich Shabalina, Svetlana A. Spiridonov, Nikolay A. Koonin, Eugene V. Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title | Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title_full | Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title_fullStr | Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title_full_unstemmed | Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title_short | Connections between Alternative Transcription and Alternative Splicing in Mammals |
| title_sort | connections between alternative transcription and alternative splicing in mammals |
| url | http://hdl.handle.net/1721.1/73061 |
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