Bifunctional Polymeric Inhibitors of Human Influenza A Viruses
Purpose: New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1 + 2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses....
Main Authors: | Haldar, Jayanta, Alvarez de Cienfuegos, Luis, Tumpey, Terrence M., Gubareva, Larisa V., Chen, Jianzhu, Klibanov, Alexander M. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Springer Science + Business Media B.V.
2012
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Online Access: | http://hdl.handle.net/1721.1/73085 https://orcid.org/0000-0003-3830-714X https://orcid.org/0000-0002-5687-6154 |
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