Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia
Recent advances in placebo research have demonstrated the mind's power to alter physiology. In this study, we combined an expectancy manipulation model with both verum and sham acupuncture treatments to address: 1) how and to what extent treatment and expectancy effects — including both subject...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2012
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| Online Access: | http://hdl.handle.net/1721.1/73102 https://orcid.org/0000-0002-7615-8440 |
| _version_ | 1811073031412383744 |
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| author | Kong, Jian Kaptchuk, Ted J. Polich, Ginger Kirsch, Irving Vangel, Mark G. Zyloney, Carolyn Rosen, Bruce R. Gollub, Randy Lyanne |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Kong, Jian Kaptchuk, Ted J. Polich, Ginger Kirsch, Irving Vangel, Mark G. Zyloney, Carolyn Rosen, Bruce R. Gollub, Randy Lyanne |
| author_sort | Kong, Jian |
| collection | MIT |
| description | Recent advances in placebo research have demonstrated the mind's power to alter physiology. In this study, we combined an expectancy manipulation model with both verum and sham acupuncture treatments to address: 1) how and to what extent treatment and expectancy effects — including both subjective pain intensity levels (pain sensory ratings) and objective physiological activations (fMRI) — interact; and 2) if the underlying mechanism of expectancy remains the same whether placebo treatment is given alone or in conjunction with active treatment. The results indicate that although verum acupuncture + high expectation and sham acupuncture + high expectation induced subjective reports of analgesia of equal magnitude, fMRI analysis showed that verum acupuncture produced greater fMRI signal decrease in pain related brain regions during application of calibrated heat pain stimuli on the right arm. We believe our study provides brain imaging evidence for the existence of different mechanisms underlying acupuncture analgesia and expectancy evoked placebo analgesia. Our results also suggest that the brain network involved in expectancy may vary under different treatment situations (verum and sham acupuncture treatment). |
| first_indexed | 2024-09-23T09:27:31Z |
| format | Article |
| id | mit-1721.1/73102 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:27:31Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/731022022-09-26T11:31:19Z Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia Kong, Jian Kaptchuk, Ted J. Polich, Ginger Kirsch, Irving Vangel, Mark G. Zyloney, Carolyn Rosen, Bruce R. Gollub, Randy Lyanne Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Vangel, Mark G. Rosen, Bruce R. Gollub, Randy Lyanne Recent advances in placebo research have demonstrated the mind's power to alter physiology. In this study, we combined an expectancy manipulation model with both verum and sham acupuncture treatments to address: 1) how and to what extent treatment and expectancy effects — including both subjective pain intensity levels (pain sensory ratings) and objective physiological activations (fMRI) — interact; and 2) if the underlying mechanism of expectancy remains the same whether placebo treatment is given alone or in conjunction with active treatment. The results indicate that although verum acupuncture + high expectation and sham acupuncture + high expectation induced subjective reports of analgesia of equal magnitude, fMRI analysis showed that verum acupuncture produced greater fMRI signal decrease in pain related brain regions during application of calibrated heat pain stimuli on the right arm. We believe our study provides brain imaging evidence for the existence of different mechanisms underlying acupuncture analgesia and expectancy evoked placebo analgesia. Our results also suggest that the brain network involved in expectancy may vary under different treatment situations (verum and sham acupuncture treatment). National Center for Complementary and Alternative Medicine (U.S.) (PO1-AT002048) National Center for Complementary and Alternative Medicine (U.S.) (R21AT00949) 2012-09-21T17:32:29Z 2012-09-21T17:32:29Z 2008-12 2008-11 Article http://purl.org/eprint/type/JournalArticle 1053-8119 1095-9572 http://hdl.handle.net/1721.1/73102 Kong, Jian et al. “Expectancy and Treatment Interactions: A Dissociation Between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia.” NeuroImage 45.3 (2009): 940–949. https://orcid.org/0000-0002-7615-8440 en_US http://dx.doi.org/10.1016/j.neuroimage.2008.12.025 NeuroImage Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier PubMed Central |
| spellingShingle | Kong, Jian Kaptchuk, Ted J. Polich, Ginger Kirsch, Irving Vangel, Mark G. Zyloney, Carolyn Rosen, Bruce R. Gollub, Randy Lyanne Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title | Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title_full | Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title_fullStr | Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title_full_unstemmed | Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title_short | Expectancy and Treatment Interactions: A Dissociation between Acupuncture Analgesia and Expectancy Evoked Placebo Analgesia |
| title_sort | expectancy and treatment interactions a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia |
| url | http://hdl.handle.net/1721.1/73102 https://orcid.org/0000-0002-7615-8440 |
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