Article The Structure of the Cataract-Causing P23T Mutant of Human

Crystallins are major proteins of the eye lens and essential for lens transparency. Mutations and aging of crystallins cause cataracts, the predominant cause of blindness in the world. In human γD-crystallin, the P23T mutant is associated with congenital cataracts. Until now, no atomic structural in...

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Bibliographic Details
Main Authors: Wang, Yongting, King, Jonathan Alan, Jung, Jinwon, Byeon, In-Ja L., Gronenborn, Angela M.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/73200
https://orcid.org/0000-0001-6174-217X