Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells
Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 d...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell (John Wiley & Sons)
2012
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| Online Access: | http://hdl.handle.net/1721.1/73479 |
| _version_ | 1826203389513433088 |
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| author | Staerk, Judith Lyssiotis, Costas A. Medeiro, Lea A. Bollong, Michael Foreman, Ruth K. Zhu, Shoutian Garcia, Michael Gao, Qing Bouchez, Laure C. Lairson, Luke L. Charette, Bradley D. Supekova, Lubica Janes, Jeffrey Brinker, Achim Cho, Charles Y. Jaenisch, Rudolf Schultz, Peter G. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Staerk, Judith Lyssiotis, Costas A. Medeiro, Lea A. Bollong, Michael Foreman, Ruth K. Zhu, Shoutian Garcia, Michael Gao, Qing Bouchez, Laure C. Lairson, Luke L. Charette, Bradley D. Supekova, Lubica Janes, Jeffrey Brinker, Achim Cho, Charles Y. Jaenisch, Rudolf Schultz, Peter G. |
| author_sort | Staerk, Judith |
| collection | MIT |
| description | Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application. |
| first_indexed | 2024-09-23T12:35:49Z |
| format | Article |
| id | mit-1721.1/73479 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:35:49Z |
| publishDate | 2012 |
| publisher | Wiley Blackwell (John Wiley & Sons) |
| record_format | dspace |
| spelling | mit-1721.1/734792022-09-28T08:53:27Z Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells Staerk, Judith Lyssiotis, Costas A. Medeiro, Lea A. Bollong, Michael Foreman, Ruth K. Zhu, Shoutian Garcia, Michael Gao, Qing Bouchez, Laure C. Lairson, Luke L. Charette, Bradley D. Supekova, Lubica Janes, Jeffrey Brinker, Achim Cho, Charles Y. Jaenisch, Rudolf Schultz, Peter G. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Foreman, Ruth K. Jaenisch, Rudolf Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c-Myc. Application of a cell-based, high-throughput chemical screen led to the identification of Src family kinase (SFK) inhibitors as chemical replacements for retroviral Sox2 delivery. These compounds are used to study the mechanisms underlying direct reprogramming and may ultimately help to bring iPS cell technology one step closer to clinical application. National Institutes of Health (U.S.) (Grant HD 045022) National Institutes of Health (U.S.) (Grant 5 R37A084198) 2012-09-28T16:48:43Z 2012-09-28T16:48:43Z 2011-05 2011-02 Article http://purl.org/eprint/type/JournalArticle 1433-7851 1521-3773 http://hdl.handle.net/1721.1/73479 Staerk, Judith et al. “Pan-Src Family Kinase Inhibitors Replace Sox2 During the Direct Reprogramming of Somatic Cells.” Angewandte Chemie International Edition 50.25 (2011): 5734–5736. en_US http://dx.doi.org/10.1002/anie.201101042 Angewandte Chemie International Edition Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell (John Wiley & Sons) PMC |
| spellingShingle | Staerk, Judith Lyssiotis, Costas A. Medeiro, Lea A. Bollong, Michael Foreman, Ruth K. Zhu, Shoutian Garcia, Michael Gao, Qing Bouchez, Laure C. Lairson, Luke L. Charette, Bradley D. Supekova, Lubica Janes, Jeffrey Brinker, Achim Cho, Charles Y. Jaenisch, Rudolf Schultz, Peter G. Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title | Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title_full | Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title_fullStr | Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title_full_unstemmed | Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title_short | Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells |
| title_sort | pan src family kinase inhibitors replace sox2 during the direct reprogramming of somatic cells |
| url | http://hdl.handle.net/1721.1/73479 |
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