Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors

Pluripotent cells can be derived from different types of somatic cells by nuclear reprogramming through the ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc. However, it is unclear whether postmitotic neurons are susceptible to direct reprogramming. Here, we show that...

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Bibliographic Details
Main Authors: Kim, Jongpil, Lengner, Christopher J., Kirak, Oktay, Hanna, Jacob, Cassady, John P., Lodato, Michael Anthony, Wu, Su, Faddah, Dina A., Steine, Eveline J., Gao, Qing, Fu, DongDong, Dawlaty, Meelad M., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Wiley Blackwell (John Wiley & Sons) 2012
Online Access:http://hdl.handle.net/1721.1/73480

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