Engineering scalable biological systems
Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, process...
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| Format: | Article |
| Language: | en_US |
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Landes Bioscience
2012
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| Online Access: | http://hdl.handle.net/1721.1/73505 https://orcid.org/0000-0002-9999-6690 |
| _version_ | 1811079681530658816 |
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| author | Lu, Timothy K. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lu, Timothy K. |
| author_sort | Lu, Timothy K. |
| collection | MIT |
| description | Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic, and performing output functions. In the last decade, significant progress has been made in developing basic designs for a wide range of biological circuits in bacteria, yeast, and mammalian systems. However, significant challenges in the construction, probing, modulation, and debugging of synthetic biological systems must be addressed in order to achieve scalable higher-complexity biological circuits. Furthermore, concomitant efforts to evaluate the safety and biocontainment of engineered organisms and address public and regulatory concerns will be necessary to ensure that technological advances are translated into real-world solutions. |
| first_indexed | 2024-09-23T11:18:58Z |
| format | Article |
| id | mit-1721.1/73505 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:18:58Z |
| publishDate | 2012 |
| publisher | Landes Bioscience |
| record_format | dspace |
| spelling | mit-1721.1/735052022-10-01T02:43:34Z Engineering scalable biological systems Lu, Timothy K. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Lu, Timothy K. Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic, and performing output functions. In the last decade, significant progress has been made in developing basic designs for a wide range of biological circuits in bacteria, yeast, and mammalian systems. However, significant challenges in the construction, probing, modulation, and debugging of synthetic biological systems must be addressed in order to achieve scalable higher-complexity biological circuits. Furthermore, concomitant efforts to evaluate the safety and biocontainment of engineered organisms and address public and regulatory concerns will be necessary to ensure that technological advances are translated into real-world solutions. 2012-10-01T15:41:03Z 2012-10-01T15:41:03Z 2010-11 2010-07 Article http://purl.org/eprint/type/JournalArticle 1949-1018 http://hdl.handle.net/1721.1/73505 Lu, Timothy K. “Engineering Scalable Biological Systems.” Bioengineered Bugs 1.6 (2010): 378–384. © 2010 Landes Bioscience https://orcid.org/0000-0002-9999-6690 en_US http://dx.doi.org/10.4161/bbug.1.6.13086 Bioengineered Bugs Creative Commons Attribution http://creativecommons.org/licenses/by/2.0/ application/pdf Landes Bioscience PubMed Central |
| spellingShingle | Lu, Timothy K. Engineering scalable biological systems |
| title | Engineering scalable biological systems |
| title_full | Engineering scalable biological systems |
| title_fullStr | Engineering scalable biological systems |
| title_full_unstemmed | Engineering scalable biological systems |
| title_short | Engineering scalable biological systems |
| title_sort | engineering scalable biological systems |
| url | http://hdl.handle.net/1721.1/73505 https://orcid.org/0000-0002-9999-6690 |
| work_keys_str_mv | AT lutimothyk engineeringscalablebiologicalsystems |