Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings
Oxidative stress during fetal development, delivery, or early postnatal life is a major cause of neuropathology, as both hypoxic and hyperoxic insults can significantly damage the developing brain. Despite the obvious need for reliable cerebral oxygenation monitoring, no technology currently exists...
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| Format: | Article |
| Language: | en_US |
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Springer-Verlag
2012
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| Online Access: | http://hdl.handle.net/1721.1/73585 https://orcid.org/0000-0002-5930-7694 https://orcid.org/0000-0002-2446-1499 |
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| author | Heldt, Thomas Kashif, Faisal Mahmood Verghese, George C. Sulemanji, Mustafa O'Leary, Heather M. Plessis, Adré J. du |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Heldt, Thomas Kashif, Faisal Mahmood Verghese, George C. Sulemanji, Mustafa O'Leary, Heather M. Plessis, Adré J. du |
| author_sort | Heldt, Thomas |
| collection | MIT |
| description | Oxidative stress during fetal development, delivery, or early postnatal life is a major cause of neuropathology, as both hypoxic and hyperoxic insults can significantly damage the developing brain. Despite the obvious need for reliable cerebral oxygenation monitoring, no technology currently exists to monitor cerebral oxygen metabolism continuously and noninvasively in infants at high risk for developing brain injury. Consequently, a rational approach to titrating oxygen supply to cerebral oxygen demand – and thus avoiding hyperoxic or hypoxic insults – is currently lacking. We present a promising method to close this crucial technology gap in the important case of neonates on conventional ventilators. By using cerebral near-infrared spectroscopy and signals from conventional ventilators, along with arterial oxygen saturation, we derive continuous (breath-by-breath) estimates of cerebral venous oxygen saturation, cerebral oxygen extraction fraction, cerebral blood flow, and cerebral metabolic rate of oxygen. The resultant estimates compare very favorably to previously reported data obtained by non-continuous and invasive means from preterm infants in neonatal critical care. |
| first_indexed | 2024-09-23T15:22:25Z |
| format | Article |
| id | mit-1721.1/73585 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:22:25Z |
| publishDate | 2012 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | mit-1721.1/735852022-09-29T14:31:19Z Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings Heldt, Thomas Kashif, Faisal Mahmood Verghese, George C. Sulemanji, Mustafa O'Leary, Heather M. Plessis, Adré J. du Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Heldt, Thomas Kashif, Faisal Mahmood Verghese, George C. Oxidative stress during fetal development, delivery, or early postnatal life is a major cause of neuropathology, as both hypoxic and hyperoxic insults can significantly damage the developing brain. Despite the obvious need for reliable cerebral oxygenation monitoring, no technology currently exists to monitor cerebral oxygen metabolism continuously and noninvasively in infants at high risk for developing brain injury. Consequently, a rational approach to titrating oxygen supply to cerebral oxygen demand – and thus avoiding hyperoxic or hypoxic insults – is currently lacking. We present a promising method to close this crucial technology gap in the important case of neonates on conventional ventilators. By using cerebral near-infrared spectroscopy and signals from conventional ventilators, along with arterial oxygen saturation, we derive continuous (breath-by-breath) estimates of cerebral venous oxygen saturation, cerebral oxygen extraction fraction, cerebral blood flow, and cerebral metabolic rate of oxygen. The resultant estimates compare very favorably to previously reported data obtained by non-continuous and invasive means from preterm infants in neonatal critical care. National Institutes of Health (U.S.) (Grant R01EB001659) National Institutes of Health (U.S.) (Grant K24NS057568) National Institutes of Health (U.S.) (Grant R21HD056009) 2012-10-04T13:06:23Z 2012-10-04T13:06:23Z 2012-02 2012-04 Article http://purl.org/eprint/type/JournalArticle 0001-6268 0942-0940 http://hdl.handle.net/1721.1/73585 Heldt, Thomas et al. “Continuous Quantitative Monitoring of Cerebral Oxygen Metabolism in Neonates by Ventilator-Gated Analysis of NIRS Recordings.” Intracranial Pressure and Brain Monitoring XIV. Ed. Martin U. Schuhmann & Marek Czosnyka. Vol. 114. Vienna: Springer Vienna, 2012. 177–180. https://orcid.org/0000-0002-5930-7694 https://orcid.org/0000-0002-2446-1499 en_US http://dx.doi.org/10.1007/978-3-7091-0956-4_34 Intracranial Pressure and Brain Monitoring XIV Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Springer-Verlag PubMed Central |
| spellingShingle | Heldt, Thomas Kashif, Faisal Mahmood Verghese, George C. Sulemanji, Mustafa O'Leary, Heather M. Plessis, Adré J. du Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title | Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title_full | Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title_fullStr | Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title_full_unstemmed | Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title_short | Continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator-gated analysis of NIRS recordings |
| title_sort | continuous quantitative monitoring of cerebral oxygen metabolism in neonates by ventilator gated analysis of nirs recordings |
| url | http://hdl.handle.net/1721.1/73585 https://orcid.org/0000-0002-5930-7694 https://orcid.org/0000-0002-2446-1499 |
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