Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model
2010 April 6
| Main Authors: | , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2012
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| Online Access: | http://hdl.handle.net/1721.1/73618 |
| _version_ | 1826207699065372672 |
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| author | Bric, Anka Miething, Cornelius Bialucha, Carl Uli Scuoppo, Claudio Zender, Lars Krasnitz, Alexander Xuan, Zhenyu Zuber, Johannes Wigler, Michael Hicks, James McCombie, Richard W. Hemann, Michael Hannon, Gregory J. Powers, Scott Lowe, Scott W. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bric, Anka Miething, Cornelius Bialucha, Carl Uli Scuoppo, Claudio Zender, Lars Krasnitz, Alexander Xuan, Zhenyu Zuber, Johannes Wigler, Michael Hicks, James McCombie, Richard W. Hemann, Michael Hannon, Gregory J. Powers, Scott Lowe, Scott W. |
| author_sort | Bric, Anka |
| collection | MIT |
| description | 2010 April 6 |
| first_indexed | 2024-09-23T13:53:35Z |
| format | Article |
| id | mit-1721.1/73618 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:53:35Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/736182022-09-28T16:52:08Z Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model Bric, Anka Miething, Cornelius Bialucha, Carl Uli Scuoppo, Claudio Zender, Lars Krasnitz, Alexander Xuan, Zhenyu Zuber, Johannes Wigler, Michael Hicks, James McCombie, Richard W. Hemann, Michael Hannon, Gregory J. Powers, Scott Lowe, Scott W. Massachusetts Institute of Technology. Department of Biology Hemann, Michael 2010 April 6 Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma model, we identified over ten candidate tumor suppressors, including Sfrp1, Numb, Mek1, and Angiopoietin 2. Several components of the DNA damage response machinery were also identified, including Rad17, which acts as a haploinsufficient tumor suppressor that responds to oncogenic stress and whose loss is associated with poor prognosis in human patients. Our results emphasize the utility of in vivo RNAi screens, identify and validate a diverse set of tumor suppressors, and have therapeutic implications. 2012-10-04T19:27:41Z 2012-10-04T19:27:41Z 2009-10 2009-07 Article http://purl.org/eprint/type/JournalArticle 1535-6108 http://hdl.handle.net/1721.1/73618 Bric, Anka et al. “Functional Identification of Tumor-Suppressor Genes Through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model.” Cancer Cell 16.4 (2009): 324–335. en_US http://dx.doi.org/10.1016/j.ccr.2009.08.015 Cancer Cell Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier PMC |
| spellingShingle | Bric, Anka Miething, Cornelius Bialucha, Carl Uli Scuoppo, Claudio Zender, Lars Krasnitz, Alexander Xuan, Zhenyu Zuber, Johannes Wigler, Michael Hicks, James McCombie, Richard W. Hemann, Michael Hannon, Gregory J. Powers, Scott Lowe, Scott W. Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title | Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title_full | Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title_fullStr | Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title_full_unstemmed | Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title_short | Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model |
| title_sort | functional identification of tumor suppressor genes through an in vivo rna interference screen in a mouse lymphoma model |
| url | http://hdl.handle.net/1721.1/73618 |
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