Measuring SPIO and Gd contrast agent magnetization using 3 T MRI
2011 October 11
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley Blackwell (John Wiley & Sons)
2012
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| Online Access: | http://hdl.handle.net/1721.1/73621 https://orcid.org/0000-0002-7637-2914 |
| _version_ | 1826213557769863168 |
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| author | Cantillon-Murphy, Padraig Wald, Lawrence L. Zahn, Markus Adalsteinsson, Elfar |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Cantillon-Murphy, Padraig Wald, Lawrence L. Zahn, Markus Adalsteinsson, Elfar |
| author_sort | Cantillon-Murphy, Padraig |
| collection | MIT |
| description | 2011 October 11 |
| first_indexed | 2024-09-23T15:51:09Z |
| format | Article |
| id | mit-1721.1/73621 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:51:09Z |
| publishDate | 2012 |
| publisher | Wiley Blackwell (John Wiley & Sons) |
| record_format | dspace |
| spelling | mit-1721.1/736212022-10-02T04:33:00Z Measuring SPIO and Gd contrast agent magnetization using 3 T MRI Cantillon-Murphy, Padraig Wald, Lawrence L. Zahn, Markus Adalsteinsson, Elfar Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Adalsteinsson, Elfar 2011 October 11 Traditional methods of measuring magnetization in magnetic fluid samples, such as vibrating sample magnetometry (VSM), are typically limited to maximum field strengths of about 1 T. This work demonstrates the ability of MRI to measure the magnetization associated with two commercial MRI contrast agents at 3 T by comparing analytical solutions to experimental imaging results for the field pattern associated with agents in cylindrical vials. The results of the VSM and fitted MRI data match closely. The method represents an improvement over VSM measurements since results are attainable at imaging field strengths. The agents investigated are Feridex, a superparamagnetic iron oxide suspension used primarily for liver imaging, and Magnevist, a paramagnetic, gadolinium-based compound used for tumors, inflammation and vascular lesions. MR imaging of the agents took place in sealed cylindrical vials in the presence of a surrounding volume of deionized water where the effects of the contrast agents had a measurable effect on the water's magnetization in the vicinity of the compartment of contrast agent. A pair of phase images were used to reconstruct a B[subscript 0] fieldmap. The resultant B[subscript 0] maps in the water region, corrected for shimming and container edge effects, were used to predict the agent's magnetization at 3 T. The results were compared with the results from VSM measurements up to 1.2 T and close correlation was observed. The technique should be of interest to those seeking quantification of the magnetization associated with magnetic suspensions beyond the traditional scope of VSM. The magnetization needs to be sufficiently strong (M[subscript s] ≳ 50 Am[superscript 2]/kg Fe for Feridex and X[subscript m] ≳ 5 × 10[superscript −5] m[superscript 3]/kg Gd for Magnevist) for a measurable dipole field in the surrounding water. For this reason, the technique is mostly suitable for undiluted agents. National Institutes of Health (U.S.) (Grant R01 EB007942) National Institutes of Health (U.S.) (Grant R01 EB006847) 2012-10-04T19:53:00Z 2012-10-04T19:53:00Z 2009-07 Article http://purl.org/eprint/type/JournalArticle 0952-3480 1099-1492 http://hdl.handle.net/1721.1/73621 Cantillon-Murphy, Pádraig et al. “Measuring SPIO and Gd Contrast Agent Magnetization Using 3 T MRI.” NMR in Biomedicine 22.8 (2009): 891–897. https://orcid.org/0000-0002-7637-2914 en_US http://dx.doi.org/10.1002/nbm.1412 NMR in Biomedicine Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell (John Wiley & Sons) PubMed Central |
| spellingShingle | Cantillon-Murphy, Padraig Wald, Lawrence L. Zahn, Markus Adalsteinsson, Elfar Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title | Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title_full | Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title_fullStr | Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title_full_unstemmed | Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title_short | Measuring SPIO and Gd contrast agent magnetization using 3 T MRI |
| title_sort | measuring spio and gd contrast agent magnetization using 3 t mri |
| url | http://hdl.handle.net/1721.1/73621 https://orcid.org/0000-0002-7637-2914 |
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