InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared
We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700−900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with...
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| פורמט: | Article |
| שפה: | en_US |
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American Chemical Society
2012
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| גישה מקוונת: | http://hdl.handle.net/1721.1/73651 https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0002-8277-5226 |
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| author | Allen, Peter M. Liu, Wenhao Chauhan, Vikash P. Lee, Jungmin Ting, Alice Y. Fukumura, Dai Jain, Rakesh K. Bawendi, Moungi G. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Allen, Peter M. Liu, Wenhao Chauhan, Vikash P. Lee, Jungmin Ting, Alice Y. Fukumura, Dai Jain, Rakesh K. Bawendi, Moungi G. |
| author_sort | Allen, Peter M. |
| collection | MIT |
| description | We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700−900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging. |
| first_indexed | 2024-09-23T09:47:54Z |
| format | Article |
| id | mit-1721.1/73651 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:47:54Z |
| publishDate | 2012 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | mit-1721.1/736512022-09-30T16:55:13Z InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared Allen, Peter M. Liu, Wenhao Chauhan, Vikash P. Lee, Jungmin Ting, Alice Y. Fukumura, Dai Jain, Rakesh K. Bawendi, Moungi G. Massachusetts Institute of Technology. Department of Chemistry Bawendi, Moungi G. Bawendi, Moungi G. Allen, Peter M. Liu, Wenhao Lee, Jungmin Ting, Alice Y. We present the synthesis of InAs quantum dots (QDs) with a ZnCdS shell with bright and stable emission in the near-infrared (NIR, 700−900 nm) region for biological imaging applications. We demonstrate how NIR QDs can image tumor vasculature in vivo at significantly deeper penetration depths and with higher contrast than visible emitting CdSe(CdS) QDs. Targeted cellular labeling is also presented and may enable multiplexed and low autofluorescence cellular imaging. National Cancer Institute (U.S.) (Grant no. R01-CA085140) National Cancer Institute (U.S.) (Grant no. R01-CA115767) National Cancer Institute (U.S.) (Grant no. R01-CA126642) National Cancer Institute (U.S.) (Grant no. P01-CA080124) National Institutes of Health (U.S.) (MIT-Harvard NIH Center for Cancer Nanotechnology Excellence (1U54-CA119349)) Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (W911NF-07-D-0004) National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (DMR-0117795) 2012-10-05T15:38:46Z 2012-10-05T15:38:46Z 2009-12 2009-09 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/73651 Allen, Peter M. et al. “InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared.” Journal of the American Chemical Society 132.2 (2010): 470–471. Web. https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0002-8277-5226 en_US http://dx.doi.org/10.1021/ja908250r Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society PMC |
| spellingShingle | Allen, Peter M. Liu, Wenhao Chauhan, Vikash P. Lee, Jungmin Ting, Alice Y. Fukumura, Dai Jain, Rakesh K. Bawendi, Moungi G. InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title | InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title_full | InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title_fullStr | InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title_full_unstemmed | InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title_short | InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared |
| title_sort | inas zncds quantum dots optimized for biological imaging in the near infrared |
| url | http://hdl.handle.net/1721.1/73651 https://orcid.org/0000-0003-2220-4365 https://orcid.org/0000-0002-8277-5226 |
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