Enantioselective Total Synthesis of (−)-Acylfulvene and (−)- Irofulven

Enantioselective Total Synthesis of (−)-Acylfulvene and (−)- Irofulven

We report our full account of the enantioselective total synthesis of (−)-acylfulvene (1) and (−)-irofulven (2), which features metathesis reactions for the rapid assembly of the molecular framework of these antitumor agents. We discuss (1) the application of an Evans Cu-catalyzed aldol addition rea...

Full description

Bibliographic Details
Main Authors: Movassaghi, Mohammad, Piersanti, Giovanni, Piizzi, Grazia, Siegel, Dustin Scott
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society 2012
Online Access:http://hdl.handle.net/1721.1/73652
https://orcid.org/0000-0003-3080-1063

Internet

http://hdl.handle.net/1721.1/73652
https://orcid.org/0000-0003-3080-1063

Similar Items