Enantioselective Total Synthesis of (−)-Acylfulvene and (−)- Irofulven
We report our full account of the enantioselective total synthesis of (−)-acylfulvene (1) and (−)-irofulven (2), which features metathesis reactions for the rapid assembly of the molecular framework of these antitumor agents. We discuss (1) the application of an Evans Cu-catalyzed aldol addition rea...
Main Authors: | Movassaghi, Mohammad, Piersanti, Giovanni, Piizzi, Grazia, Siegel, Dustin Scott |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society
2012
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Online Access: | http://hdl.handle.net/1721.1/73652 https://orcid.org/0000-0003-3080-1063 |
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