Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
available in PMC 2011 May 10.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/73937 |
| _version_ | 1811079392548356096 |
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| author | Kharas, Michael G. Lengner, Christopher J. Al-Shahrour, Fatima Bullinger, Lars Ball, Brian Zaidi, Samir Morgan, Kelly Tam, Winnie Paktinat, Mahnaz Okabe, Rachel Gozo, Maricel Einhorn, William S. Lane, Steven W. Scholl, Claudia Frohling, Stefan Fleming, Mark Ebert, Benjamin L. Gilliland, D. Gary Jaenisch, Rudolf Daley, George Q. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kharas, Michael G. Lengner, Christopher J. Al-Shahrour, Fatima Bullinger, Lars Ball, Brian Zaidi, Samir Morgan, Kelly Tam, Winnie Paktinat, Mahnaz Okabe, Rachel Gozo, Maricel Einhorn, William S. Lane, Steven W. Scholl, Claudia Frohling, Stefan Fleming, Mark Ebert, Benjamin L. Gilliland, D. Gary Jaenisch, Rudolf Daley, George Q. |
| author_sort | Kharas, Michael G. |
| collection | MIT |
| description | available in PMC 2011 May 10. |
| first_indexed | 2024-09-23T11:14:18Z |
| format | Article |
| id | mit-1721.1/73937 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:14:18Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/739372022-09-27T18:04:08Z Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia Kharas, Michael G. Lengner, Christopher J. Al-Shahrour, Fatima Bullinger, Lars Ball, Brian Zaidi, Samir Morgan, Kelly Tam, Winnie Paktinat, Mahnaz Okabe, Rachel Gozo, Maricel Einhorn, William S. Lane, Steven W. Scholl, Claudia Frohling, Stefan Fleming, Mark Ebert, Benjamin L. Gilliland, D. Gary Jaenisch, Rudolf Daley, George Q. Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Lengner, Christopher J. Zaidi, Samir Jaenisch, Rudolf available in PMC 2011 May 10. RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia–associated BCR-ABL1 oncoprotein to induce an aggressive leukemia. MSI2 is overexpressed in human myeloid leukemia cell lines, and its depletion leads to decreased proliferation and increased apoptosis. Expression levels in human myeloid leukemia directly correlate with decreased survival in patients with the disease, thereby defining MSI2 expression as a new prognostic marker and as a new target for therapy in acute myeloid leukemia (AML). Leukemia & Lymphoma Society of America National Institutes of Health (U.S.) (Ruth L. Kirschstein Fellowship) National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) ( Kidney Diseases Career Development Award) 2012-10-12T16:32:38Z 2012-10-12T16:32:38Z 2010-07 2010-04 Article http://purl.org/eprint/type/JournalArticle 1078-8956 1744-7933 http://hdl.handle.net/1721.1/73937 Kharas, Michael G. et al. “Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia.” Nature Medicine 16.8 (2010): 903–908. Web. en_US http://dx.doi.org/10.1038/nm.2187 Nature Medicine Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Kharas, Michael G. Lengner, Christopher J. Al-Shahrour, Fatima Bullinger, Lars Ball, Brian Zaidi, Samir Morgan, Kelly Tam, Winnie Paktinat, Mahnaz Okabe, Rachel Gozo, Maricel Einhorn, William S. Lane, Steven W. Scholl, Claudia Frohling, Stefan Fleming, Mark Ebert, Benjamin L. Gilliland, D. Gary Jaenisch, Rudolf Daley, George Q. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title | Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title_full | Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title_fullStr | Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title_full_unstemmed | Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title_short | Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| title_sort | musashi 2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia |
| url | http://hdl.handle.net/1721.1/73937 |
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