The landscape of somatic copy-number alteration across human cancers
available in PMC 2010 August 18.
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/73943 |
| _version_ | 1826208157219684352 |
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| author | Lander, Eric Steven |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lander, Eric Steven |
| author_sort | Lander, Eric Steven |
| collection | MIT |
| description | available in PMC 2010 August 18. |
| first_indexed | 2024-09-23T14:01:25Z |
| format | Article |
| id | mit-1721.1/73943 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:01:25Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/739432022-09-28T17:46:27Z The landscape of somatic copy-number alteration across human cancers Lander, Eric Steven Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Lander, Eric S. available in PMC 2010 August 18. A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-κΒ pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types. National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P50CA90578) National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, R01CA109038)) National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, R01CA109467) National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P01CA085859) National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, P01CA 098101) National Institutes of Health (U.S.) (Dana-Farber/Harvard Cancer Center and Pacific Northwest Prostate Cancer SPOREs, K08CA122833) 2012-10-12T18:31:53Z 2012-10-12T18:31:53Z 2010-02 Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/73943 Beroukhim, Rameen et al. “The Landscape of Somatic Copy-number Alteration Across Human Cancers.” Nature 463.7283 (2010): 899–905. Web. en_US http://dx.doi.org/10.1038/nature08822 Nature Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Lander, Eric Steven The landscape of somatic copy-number alteration across human cancers |
| title | The landscape of somatic copy-number alteration across human cancers |
| title_full | The landscape of somatic copy-number alteration across human cancers |
| title_fullStr | The landscape of somatic copy-number alteration across human cancers |
| title_full_unstemmed | The landscape of somatic copy-number alteration across human cancers |
| title_short | The landscape of somatic copy-number alteration across human cancers |
| title_sort | landscape of somatic copy number alteration across human cancers |
| url | http://hdl.handle.net/1721.1/73943 |
| work_keys_str_mv | AT landerericsteven thelandscapeofsomaticcopynumberalterationacrosshumancancers AT landerericsteven landscapeofsomaticcopynumberalterationacrosshumancancers |