Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm
The performance and imaging characteristics of ultrahigh speed ophthalmic optical coherence tomography (OCT) are investigated. In vivo imaging results are obtained at 850nm and 1050nm using different configurations of spectral and swept source / Fourier domain OCT. A spectral / Fourier domain instru...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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SPIE
2012
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| Online Access: | http://hdl.handle.net/1721.1/73961 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826197790745690112 |
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| author | Potsaid, Benjamin M. Liu, Jonathan Jaoshin Manjunath, Varsha Gorczynska, Iwona Srinivasan, Vivek J. Jiang, James Barry, Scott Cable, Alex E. Duker, Jay S. Fujimoto, James G. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Potsaid, Benjamin M. Liu, Jonathan Jaoshin Manjunath, Varsha Gorczynska, Iwona Srinivasan, Vivek J. Jiang, James Barry, Scott Cable, Alex E. Duker, Jay S. Fujimoto, James G. |
| author_sort | Potsaid, Benjamin M. |
| collection | MIT |
| description | The performance and imaging characteristics of ultrahigh speed ophthalmic optical coherence tomography (OCT) are investigated. In vivo imaging results are obtained at 850nm and 1050nm using different configurations of spectral and swept source / Fourier domain OCT. A spectral / Fourier domain instrument using a high speed CMOS linescan camera with SLD light source centered at 850nm achieves speeds of ~91,000 axial scans per second with ~3μm axial resolution in tissue. A spectral / Fourier domain instrument using an InGaAs linescan camera with SLD light source centered at 1050nm achieves ~47,000 axial scans per second with ~7μm resolution in tissue. A swept source instrument using a novel wavelength swept laser light source centered at 1050nm achieves 100,000 axial scans per second. Retinal diseases seen in the clinical setting are imaged using the 91kHz 850nm CMOS camera and 47kHz 1050nm InGaAs camera based instruments to investigate the combined effects of varying speed, axial resolution, center wavelength, and instrument sensitivity on image quality. The novel 1050nm swept source / Fourier domain instrument using a recently developed commercially available short cavity laser source images at 100,000 axial scans per second and is demonstrated in the normal retina. The dense 3D volumetric data sets obtained with ultrahigh speed OCT promise to improve reproducibility of quantitative measurements, enabling early diagnosis as well as more sensitive assessment of disease progression and response to therapy. |
| first_indexed | 2024-09-23T10:53:31Z |
| format | Article |
| id | mit-1721.1/73961 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:53:31Z |
| publishDate | 2012 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/739612022-09-30T23:43:45Z Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm Potsaid, Benjamin M. Liu, Jonathan Jaoshin Manjunath, Varsha Gorczynska, Iwona Srinivasan, Vivek J. Jiang, James Barry, Scott Cable, Alex E. Duker, Jay S. Fujimoto, James G. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Potsaid, Benjamin M. Liu, Jonathan Jaoshin Gorczynska, Iwona Srinivasan, Vivek J. Fujimoto, James G. The performance and imaging characteristics of ultrahigh speed ophthalmic optical coherence tomography (OCT) are investigated. In vivo imaging results are obtained at 850nm and 1050nm using different configurations of spectral and swept source / Fourier domain OCT. A spectral / Fourier domain instrument using a high speed CMOS linescan camera with SLD light source centered at 850nm achieves speeds of ~91,000 axial scans per second with ~3μm axial resolution in tissue. A spectral / Fourier domain instrument using an InGaAs linescan camera with SLD light source centered at 1050nm achieves ~47,000 axial scans per second with ~7μm resolution in tissue. A swept source instrument using a novel wavelength swept laser light source centered at 1050nm achieves 100,000 axial scans per second. Retinal diseases seen in the clinical setting are imaged using the 91kHz 850nm CMOS camera and 47kHz 1050nm InGaAs camera based instruments to investigate the combined effects of varying speed, axial resolution, center wavelength, and instrument sensitivity on image quality. The novel 1050nm swept source / Fourier domain instrument using a recently developed commercially available short cavity laser source images at 100,000 axial scans per second and is demonstrated in the normal retina. The dense 3D volumetric data sets obtained with ultrahigh speed OCT promise to improve reproducibility of quantitative measurements, enabling early diagnosis as well as more sensitive assessment of disease progression and response to therapy. National Institutes of Health (U.S.) (5R01-EY011289-23) National Institutes of Health (U.S.) (5R01-EY013178-09) National Institutes of Health (U.S.) (2R01-EY013516-16) National Institutes of Health (U.S.) (1R01-EY019029-01) United States. Air Force Office of Scientific Research (Contract FA9550-07-1-0014) Medical Free Electron Laser Program (Contract FA9550-07-1-0101) 2012-10-15T15:16:26Z 2012-10-15T15:16:26Z 2010-03 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/73961 Benjamin Potsaid ; Jonathan Liu ; Varsha Manjunath ; Iwona Gorczynska ; Vivek J. Srinivasan ; James Jiang ; Scott Barry ; Alex Cable ; Jay S. Duker ; James G. Fujimoto; Ultrahigh-speed volumetric ophthalmic OCT imaging at 850nm and 1050nm. Proc. SPIE 7550, Ophthalmic Technologies XX, 75501K (March 02, 2010). SPIE © 2010 https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.842846 Proceedings of SPIE--the International Society for Optical Engineering; v. 7550 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Potsaid, Benjamin M. Liu, Jonathan Jaoshin Manjunath, Varsha Gorczynska, Iwona Srinivasan, Vivek J. Jiang, James Barry, Scott Cable, Alex E. Duker, Jay S. Fujimoto, James G. Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title | Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title_full | Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title_fullStr | Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title_full_unstemmed | Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title_short | Ultrahigh speed volumetric ophthalmic OCT imaging at 850nm and 1050nm |
| title_sort | ultrahigh speed volumetric ophthalmic oct imaging at 850nm and 1050nm |
| url | http://hdl.handle.net/1721.1/73961 https://orcid.org/0000-0002-0828-4357 |
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