Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT
We performed OCT imaging of the rat retina at 70,000 axial scans per second with ~3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and impr...
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| Format: | Article |
| Language: | en_US |
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SPIE
2012
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| Online Access: | http://hdl.handle.net/1721.1/73963 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826200132684611584 |
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| author | Liu, Jonathan Jaoshin Potsaid, Benjamin M. Chen, Yueli Gorczynska, Iwona Srinivasan, Vivek J. Duker, Jay S. Fujimoto, James G. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Liu, Jonathan Jaoshin Potsaid, Benjamin M. Chen, Yueli Gorczynska, Iwona Srinivasan, Vivek J. Duker, Jay S. Fujimoto, James G. |
| author_sort | Liu, Jonathan Jaoshin |
| collection | MIT |
| description | We performed OCT imaging of the rat retina at 70,000 axial scans per second with ~3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides noninvasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment. |
| first_indexed | 2024-09-23T11:31:41Z |
| format | Article |
| id | mit-1721.1/73963 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:31:41Z |
| publishDate | 2012 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/739632022-10-01T04:11:27Z Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT Liu, Jonathan Jaoshin Potsaid, Benjamin M. Chen, Yueli Gorczynska, Iwona Srinivasan, Vivek J. Duker, Jay S. Fujimoto, James G. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Liu, Jonathan Jaoshin Potsaid, Benjamin M. Chen, Yueli Gorczynska, Iwona Srinivasan, Vivek J. Fujimoto, James G. We performed OCT imaging of the rat retina at 70,000 axial scans per second with ~3 μm axial resolution. Three-dimensional OCT (3D-OCT) data sets of the rat retina were acquired. The high speed and high density data sets enable improved en face visualization by reducing eye motion artifacts and improve Doppler OCT measurements. Minimal motion artifacts were visible and the OCT fundus images offer more precise registration of individual OCT images to retinal fundus features. Projection OCT fundus images show features such as the nerve fiber layer, retinal capillary networks and choroidal vasculature. Doppler OCT images and quantitative measurements show pulsatility in retinal blood vessels. Doppler OCT provides noninvasive in vivo quantitative measurements of retinal blood flow properties and may benefit studies of diseases such as glaucoma and diabetic retinopathy. Ultrahigh speed imaging using ultrahigh resolution spectral / Fourier domain OCT promises to enable novel protocols for measuring small animal retinal structure and retinal blood flow. This non-invasive imaging technology is a promising tool for monitoring disease progression in rat and mouse models to assess ocular disease pathogenesis and response to treatment. National Institutes of Health (U.S.) (Contract 5R01-EY011289-23) National Institutes of Health (U.S.) (Contract 5R01-EY013178-09) National Institutes of Health (U.S.) (Contract 2R01-EY013516-16) National Institutes of Health (U.S.) (Contract 1R01-EY019029-01) United States. Air Force Office of Scientific Research (FA9550-07-1-0101) United States. Air Force Office of Scientific Research (FA9550-07-1-0014) 2012-10-15T15:25:32Z 2012-10-15T15:25:32Z 2010-03 Article http://purl.org/eprint/type/JournalArticle 0277-786X http://hdl.handle.net/1721.1/73963 Jonathan J. Liu ; Benjamin Potsaid ; Yueli Chen ; Iwona Gorczynska ; Vivek J. Srinivasan ; Jay S. Duker ; James G. Fujimoto; Ultrahigh-speed imaging of the rat retina using ultrahigh-resolution spectral/Fourier domain OCT. Proc. SPIE 7550, Ophthalmic Technologies XX, 755017 (March 02, 2010). SPIE © 2010 https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.842540 Proceedings of SPIE--the International Society for Optical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Liu, Jonathan Jaoshin Potsaid, Benjamin M. Chen, Yueli Gorczynska, Iwona Srinivasan, Vivek J. Duker, Jay S. Fujimoto, James G. Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title | Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title_full | Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title_fullStr | Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title_full_unstemmed | Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title_short | Ultrahigh Speed Imaging of the Rat Retina Using Ultrahigh Resolution Spectral/Fourier Domain OCT |
| title_sort | ultrahigh speed imaging of the rat retina using ultrahigh resolution spectral fourier domain oct |
| url | http://hdl.handle.net/1721.1/73963 https://orcid.org/0000-0002-0828-4357 |
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