Promiscuous binding of extracellular peptides to cell surface class I MHC protein

Promiscuous binding of extracellular peptides to cell surface class I MHC protein

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Algorithms derived from measurements of short-peptide (8–10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K[superscript b], can bind well over 1 million different peptides with significant affinity (<500 nM), a level of ligand-binding prom...

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Bibliographic Details
Main Authors: Eisen, Herman N., Hou, Xun Helen, Shen, Chase, Wang, Kaidi, Tanguturi, Varsha Keelara, Smith, Crysela, Kozyrytska, Katerina, Nambiar, Lakshmi, McKinley, Carol A., Chen, Jianzhu, Cohen, Richard J.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/74019
https://orcid.org/0000-0002-5573-0137
https://orcid.org/0000-0002-5687-6154

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