Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase

Structure of the Nucleotide Radical Formed during Reaction of CDP/TTP with the E441Q-α2β2 of E. coli Ribonucleotide Reductase

The Escherichia coli ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleotides and requires a diferric-tyrosyl radical cofactor for catalysis. RNR is composed of a 1:1 complex of two homodimeric subunits: α and β. Incubation of the E441Q-α mutant RNR with...

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Bibliographic Details
Main Authors:	Zipse, Hendrik, Artin, Erin, Wnuk, Stanislaw, Lohman, Gregory J. S., Martino, Debora, Griffin, Robert Guy
Other Authors:	Massachusetts Institute of Technology. Department of Chemistry
Format:	Article
Language:	en_US
Published:	American Chemical Society (ACS) 2012
Online Access:	http://hdl.handle.net/1721.1/74085 https://orcid.org/0000-0003-1589-832X

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