Enzyme responsive acetaminophen hydrogels
Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators (LMWGs). Herein, we report a novel approach for controlled delivery of multi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers (IEEE)
2012
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| Online Access: | http://hdl.handle.net/1721.1/74120 |
| _version_ | 1811073471917064192 |
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| author | Vemula, Praveen Cruikshank, Gregory John, George Karp, Jeffrey Michael |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Vemula, Praveen Cruikshank, Gregory John, George Karp, Jeffrey Michael |
| author_sort | Vemula, Praveen |
| collection | MIT |
| description | Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators (LMWGs). Herein, we report a novel approach for controlled delivery of multiple drugs by an enzyme triggered hydrogel degradation mechanism. In this proof-of-concept work, we report the synthesis of LMWGs (amphiphiles) from well-known drug acetaminophen (which is known as Tylenolreg), and their ability to self-assemble into nanoscale structures in aqueous solutions to form hydrogels that subsequently encapsulate a second drug such as curcumin which is a known chemopreventive hydrophobic drug. Upon enzyme triggered degradation, hydrogels showed single and double drug delivery at physiological conditions in vitro. After treating with prodrug amphiphiles, mesenchymal stem cells (MSCs) retain their stem cell properties such as maintaining their adhesive and proliferation capacities with high viability. This new platform approach will have prospective effect on hydrogel based drug delivery research through developing drug delivery vehicles from a wide range of prodrug-based gelators. |
| first_indexed | 2024-09-23T09:33:39Z |
| format | Article |
| id | mit-1721.1/74120 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:33:39Z |
| publishDate | 2012 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/741202022-09-30T15:17:43Z Enzyme responsive acetaminophen hydrogels Vemula, Praveen Cruikshank, Gregory John, George Karp, Jeffrey Michael Harvard University--MIT Division of Health Sciences and Technology Vemula, Praveen Karp, Jeffrey Michael Utilization of enzyme catalysis as a tool to disassemble self-assembled hydrogels to control the release encapsulated drug provides an opportunity to design a wide range of enzyme-specific low-molecular-weight hydrogelators (LMWGs). Herein, we report a novel approach for controlled delivery of multiple drugs by an enzyme triggered hydrogel degradation mechanism. In this proof-of-concept work, we report the synthesis of LMWGs (amphiphiles) from well-known drug acetaminophen (which is known as Tylenolreg), and their ability to self-assemble into nanoscale structures in aqueous solutions to form hydrogels that subsequently encapsulate a second drug such as curcumin which is a known chemopreventive hydrophobic drug. Upon enzyme triggered degradation, hydrogels showed single and double drug delivery at physiological conditions in vitro. After treating with prodrug amphiphiles, mesenchymal stem cells (MSCs) retain their stem cell properties such as maintaining their adhesive and proliferation capacities with high viability. This new platform approach will have prospective effect on hydrogel based drug delivery research through developing drug delivery vehicles from a wide range of prodrug-based gelators. 2012-10-18T20:35:27Z 2012-10-18T20:35:27Z 2009-05 2009-04 Article http://purl.org/eprint/type/ConferencePaper 978-1-4244-4364-2 978-1-4244-4362-8 http://hdl.handle.net/1721.1/74120 Vemula, Praveen Kumar et al. “Enzyme Responsive Acetaminophen Hydrogels.” IEEE, 2009. 1–2. © 2009 IEEE en_US http://dx.doi.org/10.1109/NEBC.2009.4967713 Proceedings of the 2009 IEEE 35th Annual Northeast Bioengineering Conference Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Institute of Electrical and Electronics Engineers (IEEE) IEEE |
| spellingShingle | Vemula, Praveen Cruikshank, Gregory John, George Karp, Jeffrey Michael Enzyme responsive acetaminophen hydrogels |
| title | Enzyme responsive acetaminophen hydrogels |
| title_full | Enzyme responsive acetaminophen hydrogels |
| title_fullStr | Enzyme responsive acetaminophen hydrogels |
| title_full_unstemmed | Enzyme responsive acetaminophen hydrogels |
| title_short | Enzyme responsive acetaminophen hydrogels |
| title_sort | enzyme responsive acetaminophen hydrogels |
| url | http://hdl.handle.net/1721.1/74120 |
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