MicroRNAs: the primary cause or a determinant of progression in leukemia?
available in PMC 2011 October 10.
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Expert Reviews, Ltd.
2012
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| Online Access: | http://hdl.handle.net/1721.1/74196 https://orcid.org/0000-0002-7029-7415 |
| _version_ | 1810991882098966528 |
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| author | Bousquet, Marina Lodish, Harvey F. |
| author2 | Whitehead Institute for Biomedical Research |
| author_facet | Whitehead Institute for Biomedical Research Bousquet, Marina Lodish, Harvey F. |
| author_sort | Bousquet, Marina |
| collection | MIT |
| description | available in PMC 2011 October 10. |
| first_indexed | 2024-09-23T13:00:45Z |
| format | Article |
| id | mit-1721.1/74196 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:00:45Z |
| publishDate | 2012 |
| publisher | Expert Reviews, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/741962022-09-28T11:26:12Z MicroRNAs: the primary cause or a determinant of progression in leukemia? Bousquet, Marina Lodish, Harvey F. Whitehead Institute for Biomedical Research Lodish, Harvey F. Bousquet, Marina available in PMC 2011 October 10. Leukemia is a complex disease with many different types and subtypes caused by a huge diversity of genetic and epigenetic aberrations. Until recently, alterations of protein-coding genes were thought to be the sole cause of tumorigenesis. With the recent discovery of multiple types of non-coding RNAs, it has become evident that mutations in these also contribute to the development of cancer. Among the non-coding RNAs, microRNAs play a crucial role in cancer owing to their involvement in fundamental processes such as apoptosis, differentiation and proliferation. MicroRNAs are small noncoding RNAs (approximately 19–25 nucleotides in length) that bind to and downregulate multiple mRNA targets; in mammals, the production of over a third of all proteins is regulated by microRNAs [3]. Several studies demonstrated that microRNAs are involved in leukemia progression but their role as the primary cause or a determinant of progression in leukemia has been unclear. Some have been identified as oncogenes or tumor suppressor genes, which suggests that they are playing a central role in tumorigenesis, while others appear to be associated with a specific stage in disease progression. Deciphering the exact role of microRNAs in oncogenesis is important in order to improve the diagnosis and treatment of leukemia patients. National Institutes of Health (U.S.) (NIH grant DK068348) National Institutes of Health (U.S.) (NIH Grant 5P01 HL066105) Leukemia & Lymphoma Society of America (Recherche sur le Cancer (ARC) fellowship) 2012-10-22T20:17:09Z 2012-10-22T20:17:09Z 2011-04 Article http://purl.org/eprint/type/JournalArticle 1747-4086 1747-4094 http://hdl.handle.net/1721.1/74196 Bousquet, Marina, and Harvey F Lodish. “MicroRNAs: The Primary Cause or a Determinant of Progression in Leukemia?” Expert Review of Hematology 4.2 (2011): 121–123. Web. https://orcid.org/0000-0002-7029-7415 en_US http://dx.doi.org/10.1586/ehm.11.6 Expert Review of Hematology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Expert Reviews, Ltd. PMC |
| spellingShingle | Bousquet, Marina Lodish, Harvey F. MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title | MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title_full | MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title_fullStr | MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title_full_unstemmed | MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title_short | MicroRNAs: the primary cause or a determinant of progression in leukemia? |
| title_sort | micrornas the primary cause or a determinant of progression in leukemia |
| url | http://hdl.handle.net/1721.1/74196 https://orcid.org/0000-0002-7029-7415 |
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