Mouse models of osteoarthritis and joint injury
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2012
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| Online Access: | http://hdl.handle.net/1721.1/74422 |
| _version_ | 1826194289496948736 |
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| author | Avedillo, Jose Enrique |
| author2 | Alan J. Grodzinsky. |
| author_facet | Alan J. Grodzinsky. Avedillo, Jose Enrique |
| author_sort | Avedillo, Jose Enrique |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012. |
| first_indexed | 2024-09-23T09:53:46Z |
| format | Thesis |
| id | mit-1721.1/74422 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T09:53:46Z |
| publishDate | 2012 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/744222019-04-10T13:47:19Z Mouse models of osteoarthritis and joint injury Avedillo, Jose Enrique Alan J. Grodzinsky. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Massachusetts Institute of Technology. Dept. of Mechanical Engineering. Mechanical Engineering. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2012. Cataloged from PDF version of thesis. Includes bibliographical references (p. 39-40). Nearly 21 million Americans are affected by osteoarthritis, a complex disease characterized by degenerative lesions to the articular cartilage and subchondral bone in the joints. The complexity of the disease makes the use of human models impractical and complicated. Therefore, various animal models have been developed to study the progression of OA and possible therapeutic techniques. Of those models, mouse models play an integral part because of their cost-effectiveness, favorable logistics, and ability to be genetically manipulated. Three main mouse models were reviewed: (1) genetic deletion, (2) treadmill running, and (3) surgically induced injuries. Several strains of knockout mice have been develop in the past 10 years and they provide a great opportunity to study the evolution of OA. Up until now, treatment for OA has been pain management-related, but the development of more advanced mouse models has laid out the framework for possible OA preventing and repairing techniques. by Jose Enrique Avedillo. S.B. 2012-10-26T18:07:47Z 2012-10-26T18:07:47Z 2012 2012 Thesis http://hdl.handle.net/1721.1/74422 813044784 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 40 p. application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Avedillo, Jose Enrique Mouse models of osteoarthritis and joint injury |
| title | Mouse models of osteoarthritis and joint injury |
| title_full | Mouse models of osteoarthritis and joint injury |
| title_fullStr | Mouse models of osteoarthritis and joint injury |
| title_full_unstemmed | Mouse models of osteoarthritis and joint injury |
| title_short | Mouse models of osteoarthritis and joint injury |
| title_sort | mouse models of osteoarthritis and joint injury |
| topic | Mechanical Engineering. |
| url | http://hdl.handle.net/1721.1/74422 |
| work_keys_str_mv | AT avedillojoseenrique mousemodelsofosteoarthritisandjointinjury |