Fungal regulatory evolution: cis and trans in the balance
available in PMC 2010 June 17.
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2012
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| Online Access: | http://hdl.handle.net/1721.1/74507 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1811068630399451136 |
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| author | Thompson, Dawn Anne Regev, Aviv |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Thompson, Dawn Anne Regev, Aviv |
| author_sort | Thompson, Dawn Anne |
| collection | MIT |
| description | available in PMC 2010 June 17. |
| first_indexed | 2024-09-23T07:58:48Z |
| format | Article |
| id | mit-1721.1/74507 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:58:48Z |
| publishDate | 2012 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/745072022-09-23T10:01:48Z Fungal regulatory evolution: cis and trans in the balance Thompson, Dawn Anne Regev, Aviv Massachusetts Institute of Technology. Department of Biology Regev, Aviv available in PMC 2010 June 17. Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis- and trans-factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation. Human Frontier Science Program (Strasbourg, France) Howard Hughes Medical Institute Burroughs Wellcome Fund (Career Award) Alfred P. Sloan Foundation 2012-10-30T16:08:09Z 2012-10-30T16:08:09Z 2009-11 2009-11 Article http://purl.org/eprint/type/JournalArticle 0014-5793 1873-3468 http://hdl.handle.net/1721.1/74507 Thompson, Dawn Anne, and Aviv Regev. “Fungal Regulatory Evolution: Cis and Trans in the Balance.” FEBS Letters 583.24 (2009): 3959–3965. Web. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1016/j.febslet.2009.11.032 FEBS Letters Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. PMC |
| spellingShingle | Thompson, Dawn Anne Regev, Aviv Fungal regulatory evolution: cis and trans in the balance |
| title | Fungal regulatory evolution: cis and trans in the balance |
| title_full | Fungal regulatory evolution: cis and trans in the balance |
| title_fullStr | Fungal regulatory evolution: cis and trans in the balance |
| title_full_unstemmed | Fungal regulatory evolution: cis and trans in the balance |
| title_short | Fungal regulatory evolution: cis and trans in the balance |
| title_sort | fungal regulatory evolution cis and trans in the balance |
| url | http://hdl.handle.net/1721.1/74507 https://orcid.org/0000-0001-8567-2049 |
| work_keys_str_mv | AT thompsondawnanne fungalregulatoryevolutioncisandtransinthebalance AT regevaviv fungalregulatoryevolutioncisandtransinthebalance |