From elements to modules: regulatory evolution in Ascomycota fungi
available in PMC 2010 April 12.
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2012
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| Online Access: | http://hdl.handle.net/1721.1/74509 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826189601712111616 |
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| author | Wohlbach, Dana J. Thompson, Dawn Anne Gaschi, Audrey P. Regev, Aviv |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Wohlbach, Dana J. Thompson, Dawn Anne Gaschi, Audrey P. Regev, Aviv |
| author_sort | Wohlbach, Dana J. |
| collection | MIT |
| description | available in PMC 2010 April 12. |
| first_indexed | 2024-09-23T08:18:14Z |
| format | Article |
| id | mit-1721.1/74509 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:18:14Z |
| publishDate | 2012 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/745092022-09-23T12:08:59Z From elements to modules: regulatory evolution in Ascomycota fungi Wohlbach, Dana J. Thompson, Dawn Anne Gaschi, Audrey P. Regev, Aviv Massachusetts Institute of Technology. Department of Biology Regev, Aviv Wohlbach, Dana J. Gasch, Audrey P. available in PMC 2010 April 12. Regulatory divergence is likely a major driving force in evolution. Comparative transcriptomics provides a new glimpse into the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for studies of regulatory evolution, because of broad phylogenetic scope, many sequenced genomes, and facility of genomic analysis. Here we review the substantial divergence in gene expression in Ascomycota and how this is reconciled with the modular organization of transcriptional networks. We show that flexibility and redundancy in both cis-regulation and trans-regulation can lead to changes from altered expression of single genes to wholesale rewiring of regulatory modules. Redundancy thus emerges as a major driving force facilitating expression divergence while preserving the coherent functional organization of a transcriptional response. National Library of Medicine (U.S.) (NLM training grant 5T15LM007359) Burroughs Wellcome Fund (Career Award at the Scientific Interface) National Institute of General Medical Sciences (U.S.) (NIGMS R01GM083989-01) National Science Foundation (U.S.) (CAREER award (#0447887)) Human Frontier Science Program (Strasbourg, France) (Research grant) Alfred P. Sloan Foundation National Institutes of Health (U.S.) (PIONEER award) 2012-10-30T16:20:48Z 2012-10-30T16:20:48Z 2009-10 Article http://purl.org/eprint/type/JournalArticle 0959-437X http://hdl.handle.net/1721.1/74509 Wohlbach, Dana J et al. “From Elements to Modules: Regulatory Evolution in Ascomycota Fungi.” Current Opinion in Genetics & Development 19.6 (2009): 571–578. Web. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1016/j.gde.2009.09.007 Current Opinion in Genetics and Development Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Elsevier B.V. PMC |
| spellingShingle | Wohlbach, Dana J. Thompson, Dawn Anne Gaschi, Audrey P. Regev, Aviv From elements to modules: regulatory evolution in Ascomycota fungi |
| title | From elements to modules: regulatory evolution in Ascomycota fungi |
| title_full | From elements to modules: regulatory evolution in Ascomycota fungi |
| title_fullStr | From elements to modules: regulatory evolution in Ascomycota fungi |
| title_full_unstemmed | From elements to modules: regulatory evolution in Ascomycota fungi |
| title_short | From elements to modules: regulatory evolution in Ascomycota fungi |
| title_sort | from elements to modules regulatory evolution in ascomycota fungi |
| url | http://hdl.handle.net/1721.1/74509 https://orcid.org/0000-0001-8567-2049 |
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