Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling

The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling may represent therapeutic targets for human diseases. To identify novel regulat...

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Bibliographic Details
Main Authors: Lindquist, Robert A., Ottina, Kathleen, Wheeler, Douglas B., Hsu, Peggy P., Thoreen, Carson C., Guertin, David A., Ali, Siraj M., Sengupta, Shomit, Shaul, Yoav D., Lamprecht, Michael R., Madden, Katherine L., Papallo, Adam R., Jones, Thouis R., Sabatini, David M., Carpenter, Anne E.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2012
Online Access:http://hdl.handle.net/1721.1/74542
https://orcid.org/0000-0002-1446-7256

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