Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling
The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling may represent therapeutic targets for human diseases. To identify novel regulat...
Main Authors: | Lindquist, Robert A., Ottina, Kathleen, Wheeler, Douglas B., Hsu, Peggy P., Thoreen, Carson C., Guertin, David A., Ali, Siraj M., Sengupta, Shomit, Shaul, Yoav D., Lamprecht, Michael R., Madden, Katherine L., Papallo, Adam R., Jones, Thouis R., Sabatini, David M., Carpenter, Anne E. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Cold Spring Harbor Laboratory Press
2012
|
Online Access: | http://hdl.handle.net/1721.1/74542 https://orcid.org/0000-0002-1446-7256 |
Similar Items
-
Rapamycin inhibits mTORC1, but not completely
by: Thoreen, Carson C, et al.
Published: (2012) -
CellProfiler Analyst: data exploration and analysis software for complex image-based screens
by: Wheeler, Douglas B., et al.
Published: (2009) -
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
by: Carpenter, Anne E., et al.
Published: (2010) -
A unifying model for mTORC1-mediated regulation of mRNA translation
by: Thoreen, Carson C., et al.
Published: (2014) -
Nutrients versus growth factors in mTORC1 activation
by: Efeyan, Alejo, et al.
Published: (2015)