Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence
Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appr...
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2012
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| Online Access: | http://hdl.handle.net/1721.1/74553 |
| _version_ | 1826206619284799488 |
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| author | Blader, Ira J. Saeij, Jeroen |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Blader, Ira J. Saeij, Jeroen |
| author_sort | Blader, Ira J. |
| collection | MIT |
| description | Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies. |
| first_indexed | 2024-09-23T13:35:26Z |
| format | Article |
| id | mit-1721.1/74553 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:35:26Z |
| publishDate | 2012 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/745532022-10-01T15:53:17Z Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence Blader, Ira J. Saeij, Jeroen Massachusetts Institute of Technology. Department of Biology Saeij, Jeroen Toxoplasma gondii is an obligate intracellular protozoan parasite that can infect most warm-blooded animals and cause severe and life-threatening disease in developing fetuses and in immune-compromised patients. Although Toxoplasma was discovered over 100 years ago, we are only now beginning to appreciate the importance of the role that parasite modulation of its host has on parasite growth, bradyzoite development, immune evasion, and virulence. The goal of this review is to highlight these findings, to develop an integrated model for communication between Toxoplasma and its host, and to discuss new questions that arise out of these studies. American Heart Association (Scientist Development Grant 0835099N) 2012-11-01T18:52:50Z 2012-11-01T18:52:50Z 2009-04 Article http://purl.org/eprint/type/JournalArticle http://hdl.handle.net/1721.1/74553 Blader, Ira J., and Jeroen P. Saeij. “Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.” APMIS 117.5-6 (2009): 458–476. en_US http://dx.doi.org/10.1111/j.1600-0463.2009.02453.x Apmis Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Blader, Ira J. Saeij, Jeroen Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title | Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title_full | Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title_fullStr | Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title_full_unstemmed | Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title_short | Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence |
| title_sort | communication between toxoplasma gondii and its host impact on parasite growth development immune evasion and virulence |
| url | http://hdl.handle.net/1721.1/74553 |
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