THz Dynamic Nuclear Polarization NMR
Dynamic nuclear polarization (DNP) increases the sensitivity of nuclear magnetic resonance (NMR) spectroscopy by using high frequency microwaves to transfer the polarization of the electrons to the nuclear spins. The enhancement in NMR sensitivity can amount to a factor of well above 100, enabling f...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2012
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| Online Access: | http://hdl.handle.net/1721.1/74581 https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0001-9813-0177 |
| _version_ | 1826212263537672192 |
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| author | Nanni, Emilio Alessandro Barnes, Alexander Griffin, Robert Guy Temkin, Richard J |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Nanni, Emilio Alessandro Barnes, Alexander Griffin, Robert Guy Temkin, Richard J |
| author_sort | Nanni, Emilio Alessandro |
| collection | MIT |
| description | Dynamic nuclear polarization (DNP) increases the sensitivity of nuclear magnetic resonance (NMR) spectroscopy by using high frequency microwaves to transfer the polarization of the electrons to the nuclear spins. The enhancement in NMR sensitivity can amount to a factor of well above 100, enabling faster data acquisition and greatly improved NMR measurements. With the increasing magnetic fields (up to 23 T) used in NMR research, the required frequency for DNP falls into the THz band (140- 600 GHz ). Gyrotrons have been developed to meet the demanding specifications for DNP NMR, including power levels of tens of watts; frequency stability of a few megahertz; and power stability of 1% over runs that last for several days to weeks. Continuous gyrotron frequency tuning of over 1 GHz has also been demonstrated. The complete DNP NMR system must include a low loss transmission line; an optimized antenna; and a holder for efficient coupling of the THz radiation to the sample. This paper describes the DNP NMR process and illustrates the THz systems needed for this demanding spectroscopic application. THz DNP NMR is a rapidly developing, exciting area of THz science and technology. |
| first_indexed | 2024-09-23T15:18:56Z |
| format | Article |
| id | mit-1721.1/74581 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:18:56Z |
| publishDate | 2012 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/745812022-10-02T02:05:29Z THz Dynamic Nuclear Polarization NMR Nanni, Emilio Alessandro Barnes, Alexander Griffin, Robert Guy Temkin, Richard J Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Physics Massachusetts Institute of Technology. Plasma Science and Fusion Center Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) Griffin, Robert Guy Griffin, Robert Guy Temkin, Richard J. Nanni, Emilio Alessandro Barnes, Alexander Dynamic nuclear polarization (DNP) increases the sensitivity of nuclear magnetic resonance (NMR) spectroscopy by using high frequency microwaves to transfer the polarization of the electrons to the nuclear spins. The enhancement in NMR sensitivity can amount to a factor of well above 100, enabling faster data acquisition and greatly improved NMR measurements. With the increasing magnetic fields (up to 23 T) used in NMR research, the required frequency for DNP falls into the THz band (140- 600 GHz ). Gyrotrons have been developed to meet the demanding specifications for DNP NMR, including power levels of tens of watts; frequency stability of a few megahertz; and power stability of 1% over runs that last for several days to weeks. Continuous gyrotron frequency tuning of over 1 GHz has also been demonstrated. The complete DNP NMR system must include a low loss transmission line; an optimized antenna; and a holder for efficient coupling of the THz radiation to the sample. This paper describes the DNP NMR process and illustrates the THz systems needed for this demanding spectroscopic application. THz DNP NMR is a rapidly developing, exciting area of THz science and technology. National Science Foundation (U.S.) (Graduate Research Fellowship) National Institutes of Health (U.S.) (grant EB001965) National Institutes of Health (U.S.) (grant EB004866) National Institutes of Health (U.S.) (grant EB001960) National Institutes of Health (U.S.) (grant EB002804) National Institutes of Health (U.S.) (grant EB003151) National Institutes of Health (U.S.) (grant EB002026) 2012-11-06T22:04:08Z 2012-11-06T22:04:08Z 2011-09 2011-05 Article http://purl.org/eprint/type/JournalArticle 2156-342X 2156-3446 INSPEC Accession Number: 12216088 http://hdl.handle.net/1721.1/74581 Nanni, Emilio A. et al. “THz Dynamic Nuclear Polarization NMR.” IEEE Transactions on Terahertz Science and Technology 1.1 (2011): 145–163. Web. https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0001-9813-0177 en_US http://dx.doi.org/10.1109/TTHZ.2011.2159546 IEEE Transactions on Terahertz Science and Technology Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Institute of Electrical and Electronics Engineers Prof. Griffin via Erja Kajosalo |
| spellingShingle | Nanni, Emilio Alessandro Barnes, Alexander Griffin, Robert Guy Temkin, Richard J THz Dynamic Nuclear Polarization NMR |
| title | THz Dynamic Nuclear Polarization NMR |
| title_full | THz Dynamic Nuclear Polarization NMR |
| title_fullStr | THz Dynamic Nuclear Polarization NMR |
| title_full_unstemmed | THz Dynamic Nuclear Polarization NMR |
| title_short | THz Dynamic Nuclear Polarization NMR |
| title_sort | thz dynamic nuclear polarization nmr |
| url | http://hdl.handle.net/1721.1/74581 https://orcid.org/0000-0003-1589-832X https://orcid.org/0000-0001-9813-0177 |
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