Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma

Gene amplification is a tumor-specific event during malignant transformation. Recent studies have proposed a lineage-dependency (addiction) model of human cancer whereby amplification of certain lineage transcription factors predisposes a survival mechanism in tumor cells. These tumor cells are deri...

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Bibliographic Details
Main Authors: Lin, Lin, Meyerson, Matthew L., Lockwood, William W., Wang, Zhuwen, Silvers, Amy L., Bass, Adam J., Thomas, Dafydd G., Chang, Andrew C., Lin, Jules, Orringer, Mark B., Li, Weiquan, Glover, Thomas W., Giordano, Thomas J., Lam, Wan L., Beer, David G.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/74591

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