CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation
The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols that incorporate time-dependent components, we found that the loss of plastici...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2012
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| Online Access: | http://hdl.handle.net/1721.1/74649 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826190230883926016 |
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| author | McHugh, Thomas J. Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology McHugh, Thomas J. Tonegawa, Susumu |
| author_sort | McHugh, Thomas J. |
| collection | MIT |
| description | The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols that incorporate time-dependent components, we found that the loss of plasticity at recurrent CA3 synapses resulted in a deficits in contextual conditioning specifically when the exposure to the context was brief or when the unconditioned stimulus was signaled with a competing, predictive unimodal stimulus. Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning. |
| first_indexed | 2024-09-23T08:37:04Z |
| format | Article |
| id | mit-1721.1/74649 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:37:04Z |
| publishDate | 2012 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/746492022-09-23T13:18:13Z CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation McHugh, Thomas J. Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Tonegawa, Susumu McHugh, Thomas J. The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols that incorporate time-dependent components, we found that the loss of plasticity at recurrent CA3 synapses resulted in a deficits in contextual conditioning specifically when the exposure to the context was brief or when the unconditioned stimulus was signaled with a competing, predictive unimodal stimulus. Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning. 2012-11-15T17:45:15Z 2012-11-15T17:45:15Z 2009-07 2009-06 Article http://purl.org/eprint/type/JournalArticle 1050-9631 1098-1063 http://hdl.handle.net/1721.1/74649 McHugh, Thomas J., and Susumu Tonegawa. “CA3 NMDA Receptors Are Required for the Rapid Formation of a Salient Contextual Representation.” Hippocampus 19.12 (2009): 1153–1158. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1002/hipo.20684 Hippocampus Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | McHugh, Thomas J. Tonegawa, Susumu CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title | CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title_full | CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title_fullStr | CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title_full_unstemmed | CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title_short | CA3 NMDA Receptors are Required for the Rapid Formation of a Salient Contextual Representation |
| title_sort | ca3 nmda receptors are required for the rapid formation of a salient contextual representation |
| url | http://hdl.handle.net/1721.1/74649 https://orcid.org/0000-0003-2839-8228 |
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