Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography

Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D...

Full description

Bibliographic Details
Main Authors: Tsai, Tsung-Han, Zhou, Chao, Lee, Hsiang-Chieh, Tao, Yuankai Kenny, Ahsen, Osman Oguz, Figueiredo, Marisa, Adler, Desmond C., Schmitt, Joseph M., Huang, Qin, Fujimoto, James G., Mashimo, Hiroshi
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:en_US
Published: Hindawi Publishing Corporation 2012
Online Access:http://hdl.handle.net/1721.1/74704
https://orcid.org/0000-0003-4811-3429
https://orcid.org/0000-0002-0828-4357
https://orcid.org/0000-0002-2976-6195
Description
Summary:Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260  𝜇 m depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment.