Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography
Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Hindawi Publishing Corporation
2012
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| Online Access: | http://hdl.handle.net/1721.1/74704 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
| _version_ | 1811092447902564352 |
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| author | Tsai, Tsung-Han Zhou, Chao Lee, Hsiang-Chieh Tao, Yuankai Kenny Ahsen, Osman Oguz Figueiredo, Marisa Adler, Desmond C. Schmitt, Joseph M. Huang, Qin Fujimoto, James G. Mashimo, Hiroshi |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Tsai, Tsung-Han Zhou, Chao Lee, Hsiang-Chieh Tao, Yuankai Kenny Ahsen, Osman Oguz Figueiredo, Marisa Adler, Desmond C. Schmitt, Joseph M. Huang, Qin Fujimoto, James G. Mashimo, Hiroshi |
| author_sort | Tsai, Tsung-Han |
| collection | MIT |
| description | Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260
𝜇
m depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment. |
| first_indexed | 2024-09-23T15:18:00Z |
| format | Article |
| id | mit-1721.1/74704 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:18:00Z |
| publishDate | 2012 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/747042022-09-29T14:02:40Z Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography Tsai, Tsung-Han Zhou, Chao Lee, Hsiang-Chieh Tao, Yuankai Kenny Ahsen, Osman Oguz Figueiredo, Marisa Adler, Desmond C. Schmitt, Joseph M. Huang, Qin Fujimoto, James G. Mashimo, Hiroshi Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Tsai, Tsung-Han Zhou, Chao Lee, Hsiang-Chieh Tao, Yuankai Kenny Ahsen, Osman Oguz Fujimoto, James G. Two main nonsurgical endoscopic approaches for ablating dysplastic and early cancer lesions in the esophagus have gained popularity, namely, radiofrequency ablation (RFA) and cryospray ablation (CSA). We report a uniquely suited endoscopic and near-microscopic imaging modality, three-dimensional (3D) optical coherence tomography (OCT), to assess and compare the esophagus immediately after RFA and CSA. The maximum depths of architectural changes were measured and compared between the two treatment groups. RFA was observed to induce 230~260 𝜇 m depth of architectural changes after each set of ablations over a particular region, while CSA was observed to induce edema-like spongiform changes to ~640 μm depth within the ablated field. The ability to obtain micron-scale depth-resolved images of tissue structural changes following different ablation therapies makes 3D-OCT an ideal tool to assess treatment efficacy. Such information could be potentially used to provide real-time feedback for treatment dosing and to identify regions that need further retreatment. National Institutes of Health (U.S.) (Grant R01-CA75289-15) National Institutes of Health (U.S.) (Grant K99-EB010071-01A1) National Institutes of Health (U.S.) (Grant R44-CA101067-06) United States. Air Force Office of Scientific Research (Contract FA9550-10-1-0063) Medical Free Electron Laser Program (Contract FA9550-10-1-0551) 2012-11-19T19:00:43Z 2012-11-19T19:00:43Z 2012-01 2012-05 Article http://purl.org/eprint/type/JournalArticle http://hdl.handle.net/1721.1/74704 Tsai, Tsung-Han et al. “Comparison of Tissue Architectural Changes Between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography.” Gastroenterology Research and Practice 2012 (2012): 1–8. https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 en_US http://dx.doi.org/10.1155/2012/684832 Gastroenterology Research and Practice Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 application/pdf Hindawi Publishing Corporation Hindawi |
| spellingShingle | Tsai, Tsung-Han Zhou, Chao Lee, Hsiang-Chieh Tao, Yuankai Kenny Ahsen, Osman Oguz Figueiredo, Marisa Adler, Desmond C. Schmitt, Joseph M. Huang, Qin Fujimoto, James G. Mashimo, Hiroshi Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_full | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_fullStr | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_full_unstemmed | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_short | Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett’s Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography |
| title_sort | comparison of tissue architectural changes between radiofrequency ablation and cryospray ablation in barrett s esophagus using endoscopic three dimensional optical coherence tomography |
| url | http://hdl.handle.net/1721.1/74704 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
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