Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma
BALB/c nude mice 6 weeks old were inoculated with glioma C6 cell-line and the efficacy of the different amount of Etanidazole-discs and Taxol-microspheres was investigated. Poly (D,L-lactic-co-glycolic acid) (PLGA) was used as the main encapsulating polymer and polyethylene glycol was added to incre...
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| Format: | Article |
| Language: | English |
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2004
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| Online Access: | http://hdl.handle.net/1721.1/7496 |
| _version_ | 1826188197975031808 |
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| author | Naraharisetti, Pavan Kumar Lee, Timothy Kam Yiu Wang, Chi-Hwa |
| author_facet | Naraharisetti, Pavan Kumar Lee, Timothy Kam Yiu Wang, Chi-Hwa |
| author_sort | Naraharisetti, Pavan Kumar |
| collection | MIT |
| description | BALB/c nude mice 6 weeks old were inoculated with glioma C6 cell-line and the efficacy of the different amount of Etanidazole-discs and Taxol-microspheres was investigated. Poly (D,L-lactic-co-glycolic acid) (PLGA) was used as the main encapsulating polymer and polyethylene glycol was added to increase the porosity. The 1% drug loading microspheres of each drug were produced by spray drying and the discs were obtained by compressing the Etanidazole-microspheres. Intra-tumoral injection followed by irradiation resulted in high systemic dosage and thus systemic toxicity. Tumors grown for 6 days, 9 days and 16 days were implanted with 0.5 mg or 1.0 mg or 1.5 mg of the drug. A radiation dosage of 2 Gy each time for a number of times was given for animals implanted with Etanidazole and no irradiation was given for animals implanted with Taxol. Increasing the number of doses clearly decreased the rate of tumor growth. The increase in the amount of drug on smaller sized tumors controlled the tumor better and there was agglomeration of the microspheres resulting in deviation of release profile of the drug as compared to the in vitro studies. It was observed that 1.0 mg of Taxol given to a tumor grown for 6 days was able to suppress the tumor for a total period of approximately two months and no tumor resurrection was observed during the second month. |
| first_indexed | 2024-09-23T07:56:02Z |
| format | Article |
| id | mit-1721.1/7496 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T07:56:02Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | mit-1721.1/74962019-04-09T15:37:14Z Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma Naraharisetti, Pavan Kumar Lee, Timothy Kam Yiu Wang, Chi-Hwa Etanizadole Taxol Glioma tumor suppression BALB/c nude mice 6 weeks old were inoculated with glioma C6 cell-line and the efficacy of the different amount of Etanidazole-discs and Taxol-microspheres was investigated. Poly (D,L-lactic-co-glycolic acid) (PLGA) was used as the main encapsulating polymer and polyethylene glycol was added to increase the porosity. The 1% drug loading microspheres of each drug were produced by spray drying and the discs were obtained by compressing the Etanidazole-microspheres. Intra-tumoral injection followed by irradiation resulted in high systemic dosage and thus systemic toxicity. Tumors grown for 6 days, 9 days and 16 days were implanted with 0.5 mg or 1.0 mg or 1.5 mg of the drug. A radiation dosage of 2 Gy each time for a number of times was given for animals implanted with Etanidazole and no irradiation was given for animals implanted with Taxol. Increasing the number of doses clearly decreased the rate of tumor growth. The increase in the amount of drug on smaller sized tumors controlled the tumor better and there was agglomeration of the microspheres resulting in deviation of release profile of the drug as compared to the in vitro studies. It was observed that 1.0 mg of Taxol given to a tumor grown for 6 days was able to suppress the tumor for a total period of approximately two months and no tumor resurrection was observed during the second month. Singapore-MIT Alliance (SMA) 2004-12-16T05:52:53Z 2004-12-16T05:52:53Z 2005-01 Article http://hdl.handle.net/1721.1/7496 en Molecular Engineering of Biological and Chemical Systems (MEBCS); 12110 bytes application/pdf application/pdf |
| spellingShingle | Etanizadole Taxol Glioma tumor suppression Naraharisetti, Pavan Kumar Lee, Timothy Kam Yiu Wang, Chi-Hwa Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title | Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title_full | Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title_fullStr | Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title_full_unstemmed | Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title_short | Subcutaneous study on the controlled release of Etanidazole and Taxol for the treatment of Glioma |
| title_sort | subcutaneous study on the controlled release of etanidazole and taxol for the treatment of glioma |
| topic | Etanizadole Taxol Glioma tumor suppression |
| url | http://hdl.handle.net/1721.1/7496 |
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