Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

We obtained unanticipated synthetic byproducts from alkylation of the δ[superscript 1] nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-affinity byproduct, bearing a C[subscript 6]H[subscript 5](CH[subscript...

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Bibliographic Details
Main Authors: Liu, Fa, Park, Jung-Eun, Qian, Wen-Jian, Gräber, Martin, Berg, Thorsten, Lee, Kyung S., Lim, Daniel Cham-Chin, Yaffe, Michael B, Burke, Terrence R.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/75076
https://orcid.org/0000-0002-9547-3251

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