Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins s...

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Bibliographic Details
Main Authors: Simberg, Dmitri, Park, Ji-Ho, Karmali, Priya P., Zhang, Wan-Ming, Merkulov, Sergei, McCrae, Keith, Bhatia, Sangeeta N., Sailor, Michael, Ruoslahti, Erkki
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2012
Online Access:http://hdl.handle.net/1721.1/75311
https://orcid.org/0000-0002-1293-2097

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http://hdl.handle.net/1721.1/75311
https://orcid.org/0000-0002-1293-2097

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