Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance
In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins s...
Main Authors: | Simberg, Dmitri, Park, Ji-Ho, Karmali, Priya P., Zhang, Wan-Ming, Merkulov, Sergei, McCrae, Keith, Bhatia, Sangeeta N., Sailor, Michael, Ruoslahti, Erkki |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2012
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Online Access: | http://hdl.handle.net/1721.1/75311 https://orcid.org/0000-0002-1293-2097 |
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