17(lowercase beta)-estradiol and Tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice

17(lowercase beta)-estradiol and Tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice

Helicobacter pylori infection promotes male predominant gastric adenocarcinoma in humans. Estrogens reduce gastric cancer risk and previous studies showed that prophylactic 17β-estradiol (E2) in INS-GAS mice decreases H. pylori–induced carcinogenesis. We examined the effect of E2 and tamoxifen (TAM)...

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Bibliographic Details
Main Authors:	Sheh, Alexander, Ge, Zhongming, Parry, Nicola Maria Anne, Muthupalani, Sureshkumar, Rager, Julia E., Raczynski, Arkadiusz R., Mobley, Melissa W., McCabe, Amanda F., Fry, Rebecca C., Wang, Timothy C., Fox, James G.
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	American Association for Cancer Research 2012
Online Access:	http://hdl.handle.net/1721.1/75424 https://orcid.org/0000-0001-9307-6116

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