High-order chromatin architecture determines the landscape of chromosomal alterations in cancer
Author Manuscript 2012 June 01.
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2012
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| Online Access: | http://hdl.handle.net/1721.1/75436 https://orcid.org/0000-0002-0785-5410 |
| _version_ | 1811096632350998528 |
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| author | Fudenberg, Geoffrey Getz, Gad Meyerson, Matthew L. Mirny, Leonid A. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Fudenberg, Geoffrey Getz, Gad Meyerson, Matthew L. Mirny, Leonid A. |
| author_sort | Fudenberg, Geoffrey |
| collection | MIT |
| description | Author Manuscript 2012 June 01. |
| first_indexed | 2024-09-23T16:46:43Z |
| format | Article |
| id | mit-1721.1/75436 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:46:43Z |
| publishDate | 2012 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/754362021-09-09T17:20:38Z High-order chromatin architecture determines the landscape of chromosomal alterations in cancer Fudenberg, Geoffrey Getz, Gad Meyerson, Matthew L. Mirny, Leonid A. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Physics Massachusetts Institute of Technology. School of Engineering Getz, Gad Meyerson, Matthew L. Mirny, Leonid A. Author Manuscript 2012 June 01. The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. Here we test evidence supporting the influence of two major forces, spatial chromosome structure and purifying (or negative) selection, on the landscape of somatic copy-number alterations (SCNAs) in cancer[superscript 1]. Using a maximum likelihood approach, we compare SCNA maps and three-dimensional genome architecture as determined by genome-wide chromosome conformation capture (HiC) and described by the proposed fractal-globule model[superscript 2, 3]. This analysis suggests that the distribution of chromosomal alterations in cancer is spatially related to three-dimensional genomic architecture and that purifying selection, as well as positive selection, influences SCNAs during somatic evolution of cancer cells. National Institutes of Health (U.S.) (National Cancer Institute (U.S.). Physical Sciences-Oncology Center U54CA143874) National Institutes of Health (U.S.) (U24CA143845) National Institutes of Health (U.S.) (U24CA144025) National Institutes of Health (U.S.) (U24CA143867) National Cancer Institute (U.S.). (The Cancer Genome Atlas Project Investigator) 2012-12-12T19:58:18Z 2012-12-12T19:58:18Z 2011-11 2011-09 Article http://purl.org/eprint/type/JournalArticle 1087-0156 1546-1696 http://hdl.handle.net/1721.1/75436 Fudenberg, Geoff et al. “High Order Chromatin Architecture Shapes the Landscape of Chromosomal Alterations in Cancer.” Nature Biotechnology 29.12 (2011): 1109–1113. https://orcid.org/0000-0002-0785-5410 en_US http://dx.doi.org/10.1038/nbt.2049 Nature Biotechnology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Fudenberg, Geoffrey Getz, Gad Meyerson, Matthew L. Mirny, Leonid A. High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title | High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title_full | High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title_fullStr | High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title_full_unstemmed | High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title_short | High-order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| title_sort | high order chromatin architecture determines the landscape of chromosomal alterations in cancer |
| url | http://hdl.handle.net/1721.1/75436 https://orcid.org/0000-0002-0785-5410 |
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