Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-terminal Fragments

Mechanistic Investigation of the Inhibition of Aβ42 Assembly and Neurotoxicity by Aβ42 C-terminal Fragments

Oligomeric forms of amyloid β-protein (Aβ) are key neurotoxins in Alzheimer’s disease (AD). Previously, we found that C-terminal fragments (CTFs) of Aβ42 interfered with assembly of full-length Aβ42 and inhibited Aβ42-induced toxicity. To decipher the mechanism(s) by which CTFs affect Aβ42 assembly...

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Bibliographic Details
Main Authors: Li, Huiyuan, Monien, Bernhard H., Lomakin, Aleksey, Zemel, Reeve, Fradinger, Erica A., Tan, Miao, Spring, Sean M., Urbanc, Brigita, Xie, Cui-Wei, Benedek, George B., Bitan, Gal
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2013
Online Access:http://hdl.handle.net/1721.1/76186
https://orcid.org/0000-0003-2414-524X

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