Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-Ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas Sp Ox1

Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-Ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas Sp Ox1

In all structurally characterized bacterial multicomponent monooxygenase (BMM) hydroxylase proteins, a series of hydrophobic cavities in the α-subunit trace a conserved path from the protein exterior to the carboxylate-bridged diiron active site. This study examines these cavities as a potential rou...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	McCormick, Michael S., Lippard, Stephen J.
अन्य लेखक:	Massachusetts Institute of Technology. Department of Chemistry
स्वरूप:	लेख
भाषा:	en_US
प्रकाशित:	American Chemical Society 2013
ऑनलाइन पहुंच:	http://hdl.handle.net/1721.1/76212 https://orcid.org/0000-0002-2693-4982

समान संसाधन

Multiple Roles of Component Proteins in Bacterial Multicomponent Monooxygenases: Phenol Hydroxylase and Toluene/o-Xylene Monooxygenase from Pseudomonas sp. OX1
द्वारा: Tinberg, Christine E., और अन्य
प्रकाशित: (2012)

Structural investigations of hydroxylase proteins and complexes in bacterial multicomponent monooxygenase systems
द्वारा: McCormick, Michael S. (Michael Scott)
प्रकाशित: (2008)

Characterization of a Peroxodiiron(III) Intermediate in the T201S Variant of Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas sp. OX1
द्वारा: Song, Woon Ju, और अन्य
प्रकाशित: (2013)

Dioxygen activation and substrate hydroxylation by the hydroxylase component of toluene/O-xylene monooxygenase from pseudomonas sporium OX1
द्वारा: Murray, Leslie Justin
प्रकाशित: (2008)

Insights into the different dioxygen activation pathways of methane and toluene monooxygenase hydroxylases
द्वारा: Bochevarov, Arteum D., और अन्य
प्रकाशित: (2012)

Phenol degradation and molecular analysis of phenol hydroxylase from Pseudomonas cedrina
द्वारा: Tengku Kamrul, Tengku Nur Saleha
प्रकाशित: (2015)

Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase
द्वारा: Song, Woon Ju, और अन्य
प्रकाशित: (2011)

Mechanistic Studies of Reactions of Peroxodiiron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase
द्वारा: Lippard, Stephen J., और अन्य
प्रकाशित: (2012)

Phenol degradation and molecular analysis of phenol hydroxylase from Acinetobacter sp.
द्वारा: Mohamad Rashid, Muhamad Syirhan Akmal
प्रकाशित: (2015)

Structural studies of the hydroxylase component of methane monooxygenase from methyloccous capsulatus
द्वारा: Rosenzweig, Amy Claire
प्रकाशित: (2005)

Coupling Oxygen Consumption with Hydrocarbon Oxidation in Bacterial Multicomponent Monooxygenases
द्वारा: Wang, Weixue, और अन्य
प्रकाशित: (2017)

Substrate selectivity of prolyl hydroxylases
द्वारा: McDonough, M
प्रकाशित: (2018)

Oxidation Reactions Performed by Soluble Methane Monooxygenase Hydroxylase Intermediates H[subscript peroxo] and Q Proceed by Distinct Mechanisms
द्वारा: Tinberg, Christine E., और अन्य
प्रकाशित: (2011)

Exploring the reactivity of bacterial multicomponent monooxygenases
द्वारा: Tinberg, Christine Elaine
प्रकाशित: (2011)

Control of substrate access to the active site in methane monooxygenase
द्वारा: Lee, Seung Jae, और अन्य
प्रकाशित: (2013)

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
द्वारा: Rydzik, A, और अन्य
प्रकाशित: (2014)

Exploring reactivity and component interactions in Toluene/o-Xylene Monooxygenase from pseudomonas sp. OX1
द्वारा: Liang, Alexandria Deliz
प्रकाशित: (2015)

Phenol degradation and molecular validation of phenol hydroxylase gene of Alcaligenes faecalis
द्वारा: Abdul Habib, Nur Muhamad Syahir
प्रकाशित: (2015)

Biodegradation of phenol by locally isolated Acinetobacter sp. strain AQ5NOL 1 and purification of phenol hydroxylase
द्वारा: Ahmad, Siti Aqlima
प्रकाशित: (2011)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
द्वारा: Lippl, K, और अन्य
प्रकाशित: (2015)

Structural studies of bacterial multicomponent monooxygenases : insights into substrate specificity, diiron center tuning and component interactions
द्वारा: Sazinsky, Matthew H. (Matthew Howard), 1976-
प्रकाशित: (2005)

Mechanism of Substrate Activation by Tryptophan Hydroxylase: A Computational Study
द्वारा: Dr. Thirakorn Mokkawes, और अन्य
प्रकाशित: (2025-01-01)

Prolyl hydroxylases and therapeutics.
द्वारा: Smith, T, और अन्य
प्रकाशित: (2010)

Studies on HIF hydroxylases
द्वारा: Webb, J
प्रकाशित: (2008)

Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles
द्वारा: Smart, TJ, और अन्य
प्रकाशित: (2019)

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.
द्वारा: Barr, M, और अन्य
प्रकाशित: (2007)

Oxygen sensing by HIF hydroxylases.
द्वारा: Schofield, C, और अन्य
प्रकाशित: (2004)

Direct electrochemistry of pentachlorophenol hydroxylase
द्वारा: Xie, W, और अन्य
प्रकाशित: (2001)

Regulation of HIF: prolyl hydroxylases.
द्वारा: Stolze, I, और अन्य
प्रकाशित: (2006)

Therapeutic manipulation of the HIF hydroxylases.
द्वारा: Nagel, S, और अन्य
प्रकाशित: (2010)

Direct electrochemistry of pentachlorophenol hydroxylase.
द्वारा: Xie, W, और अन्य
प्रकाशित: (2001)

Signalling hypoxia by HIF hydroxylases.
द्वारा: Schofield, C, और अन्य
प्रकाशित: (2005)

Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66.
द्वारा: Türkmen, VA, और अन्य
प्रकाशित: (2023)

Understanding orchestrated chemical reactions in toluene/o-xylene monooxygenase from pseudomonas sporium OX1
द्वारा: Song, Woon Ju
प्रकाशित: (2011)

Tumour suppression by a protein hydroxylase
द्वारा: Zayer, A, और अन्य
प्रकाशित: (2016)

Structural and mechanistic studies on prolyl hydroxylases
द्वारा: Chowdhury, R
प्रकाशित: (2008)

Inhibition of a viral prolyl hydroxylase
द्वारा: Langley, G, और अन्य
प्रकाशित: (2019)

Suicide and tryptophan hydroxylase: An investigation in completers
द्वारा: Turecki, G, और अन्य
प्रकाशित: (2001)

Investigation of ʟ-amino acid hydroxylases
द्वारा: Smart, T
प्रकाशित: (2015)

The HIF hydroxylase pathway and the tumour microenvironment
द्वारा: Ratcliffe, P
प्रकाशित: (2008)