Mixing and Dispersion in Small-Scale Flow Systems
Continuous flow chemistry is being used increasingly; however, without detailed knowledge of reaction engineering, it can be difficult to judge whether dispersion and mixing are important factors on reaction outcome. Understanding these effects can result in improved choices of reactor dimensions an...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2013
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| Online Access: | http://hdl.handle.net/1721.1/76275 https://orcid.org/0000-0001-7192-580X https://orcid.org/0000-0002-8601-7799 |
| _version_ | 1811089008541827072 |
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| author | Nagy, Kevin David Shen, Bo Jamison, Timothy F. Jensen, Klavs F. |
| author2 | Novartis-MIT Center for Continuous Manufacturing |
| author_facet | Novartis-MIT Center for Continuous Manufacturing Nagy, Kevin David Shen, Bo Jamison, Timothy F. Jensen, Klavs F. |
| author_sort | Nagy, Kevin David |
| collection | MIT |
| description | Continuous flow chemistry is being used increasingly; however, without detailed knowledge of reaction engineering, it can be difficult to judge whether dispersion and mixing are important factors on reaction outcome. Understanding these effects can result in improved choices of reactor dimensions and give insight for reactor scale-up. We provide an overview of both dispersive and mixing effects in flow systems and present simple relationships for determining whether mixing or dispersion is important for a given flow system. These results are summarized in convenient charts to enable the experimentalist to identify conditions with potential mixing or dispersion problems. The information also expedites design changes, such as inclusion or changes of mixers and changes in reaction tube diameters. As a case study, application of the principles to a glycosylation reaction results in increased throughput and cleaner product profiles compared to previously reported results. |
| first_indexed | 2024-09-23T14:12:23Z |
| format | Article |
| id | mit-1721.1/76275 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:12:23Z |
| publishDate | 2013 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/762752022-10-01T19:44:39Z Mixing and Dispersion in Small-Scale Flow Systems Nagy, Kevin David Shen, Bo Jamison, Timothy F. Jensen, Klavs F. Novartis-MIT Center for Continuous Manufacturing Massachusetts Institute of Technology. Department of Chemical Engineering Jamison, Timothy F. Nagy, Kevin David Shen, Bo Jamison, Timothy F. Jensen, Klavs F. Continuous flow chemistry is being used increasingly; however, without detailed knowledge of reaction engineering, it can be difficult to judge whether dispersion and mixing are important factors on reaction outcome. Understanding these effects can result in improved choices of reactor dimensions and give insight for reactor scale-up. We provide an overview of both dispersive and mixing effects in flow systems and present simple relationships for determining whether mixing or dispersion is important for a given flow system. These results are summarized in convenient charts to enable the experimentalist to identify conditions with potential mixing or dispersion problems. The information also expedites design changes, such as inclusion or changes of mixers and changes in reaction tube diameters. As a case study, application of the principles to a glycosylation reaction results in increased throughput and cleaner product profiles compared to previously reported results. Novartis-MIT Center for Continuous Manufacturing 2013-01-17T14:17:18Z 2013-01-17T14:17:18Z 2012-01 2011-12 Article http://purl.org/eprint/type/JournalArticle 1083-6160 1520-586X http://hdl.handle.net/1721.1/76275 Nagy, Kevin D. et al. “Mixing and Dispersion in Small-Scale Flow Systems.” Organic Process Research & Development 16.5 (2012): 976–981. https://orcid.org/0000-0001-7192-580X https://orcid.org/0000-0002-8601-7799 en_US http://dx.doi.org/10.1021/op200349f Organic Process Research & Development Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) Prof. Jamison via Erja Kajosalo |
| spellingShingle | Nagy, Kevin David Shen, Bo Jamison, Timothy F. Jensen, Klavs F. Mixing and Dispersion in Small-Scale Flow Systems |
| title | Mixing and Dispersion in Small-Scale Flow Systems |
| title_full | Mixing and Dispersion in Small-Scale Flow Systems |
| title_fullStr | Mixing and Dispersion in Small-Scale Flow Systems |
| title_full_unstemmed | Mixing and Dispersion in Small-Scale Flow Systems |
| title_short | Mixing and Dispersion in Small-Scale Flow Systems |
| title_sort | mixing and dispersion in small scale flow systems |
| url | http://hdl.handle.net/1721.1/76275 https://orcid.org/0000-0001-7192-580X https://orcid.org/0000-0002-8601-7799 |
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