Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation

Networks link antigenic and receptor-binding sites of influenza hemagglutinin: Mechanistic insight into fitter strain propagation

Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions...

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Bibliographic Details
Main Authors: Soundararajan, Venkataramanan, Patel, Neel, Warnock, Ken, Wilson, Ian A., Raguram, S., Sasisekharan, V., Sasisekharan, Ram, Zheng, Shu, M. Eng. Massachusetts Institute of Technology, Raman, Rahul
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2013
Online Access:http://hdl.handle.net/1721.1/76314
https://orcid.org/0000-0002-2085-7840

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