Synthetic biology: Understanding biological design from synthetic circuits
An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological systems — from synthetic promoters to the control of cell–cell interactions —...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2013
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| Online Access: | http://hdl.handle.net/1721.1/76648 |
| _version_ | 1826214197644492800 |
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| author | Mukherji, Shankar van Oudenaarden, Alexander |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Mukherji, Shankar van Oudenaarden, Alexander |
| author_sort | Mukherji, Shankar |
| collection | MIT |
| description | An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological systems — from synthetic promoters to the control of cell–cell interactions — has contributed to our understanding of how endogenous systems are put together and function. Synthetic biological devices allow us to grasp intuitively the ranges of behaviour generated by simple biological circuits, such as linear cascades and interlocking feedback loops, as well as to exert control over natural processes, such as gene expression and population dynamics. |
| first_indexed | 2024-09-23T16:01:38Z |
| format | Article |
| id | mit-1721.1/76648 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:01:38Z |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/766482022-09-29T17:43:25Z Synthetic biology: Understanding biological design from synthetic circuits Mukherji, Shankar van Oudenaarden, Alexander Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Physics Mukherji, Shankar van Oudenaarden, Alexander An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological systems — from synthetic promoters to the control of cell–cell interactions — has contributed to our understanding of how endogenous systems are put together and function. Synthetic biological devices allow us to grasp intuitively the ranges of behaviour generated by simple biological circuits, such as linear cascades and interlocking feedback loops, as well as to exert control over natural processes, such as gene expression and population dynamics. 2013-01-30T15:35:03Z 2013-01-30T15:35:03Z 2009-11 Article http://purl.org/eprint/type/JournalArticle 1471-0056 1471-0064 http://hdl.handle.net/1721.1/76648 Mukherji, Shankar, and Alexander van Oudenaarden. “Synthetic Biology: Understanding Biological Design from Synthetic Circuits.” Nature Reviews Genetics (2009) en_US http://dx.doi.org/10.1038/nrg2697 Nature Reviews Genetics Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Mukherji, Shankar van Oudenaarden, Alexander Synthetic biology: Understanding biological design from synthetic circuits |
| title | Synthetic biology: Understanding biological design from synthetic circuits |
| title_full | Synthetic biology: Understanding biological design from synthetic circuits |
| title_fullStr | Synthetic biology: Understanding biological design from synthetic circuits |
| title_full_unstemmed | Synthetic biology: Understanding biological design from synthetic circuits |
| title_short | Synthetic biology: Understanding biological design from synthetic circuits |
| title_sort | synthetic biology understanding biological design from synthetic circuits |
| url | http://hdl.handle.net/1721.1/76648 |
| work_keys_str_mv | AT mukherjishankar syntheticbiologyunderstandingbiologicaldesignfromsyntheticcircuits AT vanoudenaardenalexander syntheticbiologyunderstandingbiologicaldesignfromsyntheticcircuits |