Dendritic cell nediated inhibition of lentiviral infection
Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and re...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Biomed Central Ltd.
2013
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| Online Access: | http://hdl.handle.net/1721.1/76670 https://orcid.org/0000-0002-5687-6154 |
| _version_ | 1824457832483782656 |
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| author | Drake, Adam Browne, Edward P. Phennicie, Ryan T. Chen, Jianzhu |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Drake, Adam Browne, Edward P. Phennicie, Ryan T. Chen, Jianzhu |
| author_sort | Drake, Adam |
| collection | MIT |
| description | Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and receiving survival signals from self peptides. This makes the dendritic cell:T cell interaction an ideal checkpoint to contain lentiviral infection of quiescent lypmhocytes. |
| first_indexed | 2024-09-23T09:56:06Z |
| format | Article |
| id | mit-1721.1/76670 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:56:06Z |
| publishDate | 2013 |
| publisher | Biomed Central Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/766702022-09-30T17:48:27Z Dendritic cell nediated inhibition of lentiviral infection Drake, Adam Browne, Edward P. Phennicie, Ryan T. Chen, Jianzhu Koch Institute for Integrative Cancer Research at MIT Drake, Adam Browne, Edward P. Phennicie, Ryan T. Chen, J. Lentiviral entry to quiescent lymphocytes represents a 'time bomb' waiting for cellular activation to spread infection. In order to undergo immune activation T cells interact with dendritic cells presenting peptide:MHC complexes 'sampling' them to look for agonist peptides and receiving survival signals from self peptides. This makes the dendritic cell:T cell interaction an ideal checkpoint to contain lentiviral infection of quiescent lypmhocytes. 2013-01-30T18:41:08Z 2013-01-30T18:41:08Z 2012-09 Article http://purl.org/eprint/type/JournalArticle 1742-4690 http://hdl.handle.net/1721.1/76670 Drake, A et al. “Dendritic Cell Nediated Inhibition of Lentiviral Infection.” Retrovirology 9.Suppl 2 (2012): P178. https://orcid.org/0000-0002-5687-6154 en_US http://dx.doi.org/10.1186/1742-4690-9-s2-p178 Retrovirology Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 application/pdf Biomed Central Ltd. BioMed Central |
| spellingShingle | Drake, Adam Browne, Edward P. Phennicie, Ryan T. Chen, Jianzhu Dendritic cell nediated inhibition of lentiviral infection |
| title | Dendritic cell nediated inhibition of lentiviral infection |
| title_full | Dendritic cell nediated inhibition of lentiviral infection |
| title_fullStr | Dendritic cell nediated inhibition of lentiviral infection |
| title_full_unstemmed | Dendritic cell nediated inhibition of lentiviral infection |
| title_short | Dendritic cell nediated inhibition of lentiviral infection |
| title_sort | dendritic cell nediated inhibition of lentiviral infection |
| url | http://hdl.handle.net/1721.1/76670 https://orcid.org/0000-0002-5687-6154 |
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